Table of Contents
Chromatography Research International
Volume 2013 (2013), Article ID 747060, 7 pages
Research Article

A New Validated Stability Indicating RP-HPLC Method for Simultaneous Estimation of Pyridoxine Hydrochloride and Meclizine Hydrochloride in Pharmaceutical Solid Dosage Forms

Quality Assurance Department, ACI Ltd., Narayanganj 1400, Bangladesh

Received 1 February 2013; Accepted 28 March 2013

Academic Editor: Irene Panderi

Copyright © 2013 Md. Saddam Nawaz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

According to ICH (International Conference on Harmonization) Q2 (R1), linearity should be evaluated by visual inspection of a plot of signals as a function of analyte concentration or content and if found linear, test results should be evaluated by appropriate statistical methods. In this proposed method the linear regression equation for PYH was found y = 6980322x + 56058 (R2 = 0.999) as well as for MYH was found y = 5330928x + 2255 (R2 = 1.000) by plotting peak area (y) versus the concentration (x). The results show that an excellent correlation exists between peak areas and concentration of drugs.

  1. Supplementary Figure