Research Article

Stability Study of Darunavir Ethanolate Tablets Applying a New Stability-Indicating HPLC Method

Table 5

Analytical parameters and their variations.

ParametersVariations

AChromatographic columnA: Waters Symmetrya
a: Agilenta
BWavelengthB: 267 nm
b: 268 nm
b′: 266 nm
CFlow rateC: 1.0 mL/min
c: 1.1 mL/min
c′: 0.9 mL/min
DMobile phaseD: 50 : 50b
d: 55 : 45b
d′: 45 : 55b
ESonication timeE: 10 min
e: 11 min
e′: 9 min
FRoom temperatureF: 25°C
f: 20°C
GAcetonitrile brandG: JTBaker
g: Tedia

aC18, 250 × 4.6 mm, 5 µm; bacetonitrile : water.