Stress Degradation Studies on Flupirtine Maleate Using Stability-Indicating RP-HPLC Method

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Parameter</td><td align="center">Flupirtine maleate</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">Linearity</td><td align="center">20–150 <svg height="12.125" id="M8" style="vertical-align:-3.50804pt" version="1.1" viewbox="0 0 8.8249998 12.125" width="8.8249998" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,7.7)"><path d="M498 54l10 -26q-13 -16 -37 -28t-48 -12q-31 0 -52 21.5t-26 56.5h-2q-69 -78 -134 -78q-52 0 -81 42h-4v-16q-1 -56 12 -141.5t25 -117.5l-13 -12q-16 1 -39.5 14t-35.5 25q-2 7 -2 259v294q0 60 -3 96l81 18q2 -23 2 -105v-171q0 -65 27.5 -94t63.5 -29q56 0 100 53
v328l80 18v-335q0 -70 41 -70q17 0 35 10z" id="x3BC"></path></g>
</svg>g/mL</td></tr><tr><td align="left">Correlation coefficient</td><td align="center">0.9996</td></tr><tr><td align="left">Slope</td><td align="center">30296</td></tr><tr><td align="left">Intercept</td><td align="center">15084</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Linearity regression data of flupirtine maleate (<svg height="11.125" id="M7" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.125" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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q42 56 97 103.5t96 71.5q46 26 74 26q9 0 16 -2.5t14 -11.5t9.5 -24.5t-1 -44t-13.5 -68.5q-30 -117 -47 -200q-4 -19 -3.5 -25t6.5 -6q21 0 70 48z" id="x1D45B"></path></g><g transform="matrix(.017,-0,0,-.017,13.305,10.862)"><path d="M535 323h-483v50h483v-50zM535 138h-483v50h483v-50z" id="x3D"></path></g><g transform="matrix(.017,-0,0,-.017,28.008,10.862)"><path d="M285 378v-2q65 -13 102 -54.5t37 -97.5q0 -57 -30.5 -104.5t-74 -75t-85.5 -42t-72 -14.5q-31 0 -59.5 11t-40.5 23q-19 18 -16 36q1 16 23 33q13 10 24 0q58 -51 124 -51q55 0 88 40t33 112q0 64 -39 96.5t-88 32.5q-29 0 -64 -11l-6 29q77 25 118 57.5t41 84.5
q0 45 -26.5 69.5t-68.5 24.5q-67 0 -120 -79l-20 20l43 63q51 56 127 56h1q66 0 107 -37t41 -95q0 -42 -31 -71q-22 -23 -68 -54z" id="x33"></path></g>
</svg>).

Chromatography Research International

tab1

Table 1

Table 1: Stress Degradation Studies on Flupirtine Maleate Using Stability-Indicating RP-HPLC Method 