Research Article
Validated HPLC Method for Quantification of Pregabalin in Human Plasma Using 1-Fluoro-2,4-dinitrobenzene as Derivatization Agent
Table 2
Precision and accuracy of method for determination of pregabalin in standard solutions (
; five sets for 3 days).
| | Nominal concentration (ng/mL) | Intraday () | Interday () | | Determined (ng/mL) | RSD (%) | Error (%) | Determined (ng/mL) | RSD (%) | Error (%) |
| | 1.00 | 1.07 | 10.5 | 7.0 | 1.08 | 12.7 | 8.0 | | 5.00 | 5.17 | 8.1 | 3.4 | 5.23 | 10.7 | 4.6 | | 75.00 | 78.10 | 6.2 | 4.1 | 70.33 | 10.1 | | | 450.00 | 438.40 | 4.3 | | 413.87 | 4.7 | | | 550.00 | 528.50 | 6.4 | | 511.17 | 8.3 | | | 2500.00 | 2419.53 | 8.6 | | 2404.67 | 8.9 | | | 4500.00 | 4679.77 | 10.2 | 4.0 | 4325.10 | 10.4 | |
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