Development and Validation of a Novel RP-HPLC Method for Estimation of Losartan Potassium in Dissolution Samples of Immediate and Sustained Release Tablets

Table 1

Quantitative solubility of Losartan potassium in different medium.

Dissolution medium	Solubility in mg/mL^a	S.D.
Purified water	97.058	0.09
0.1 N HCl	4.573	0.02
pH 1.2 acetate buffer	4.585	0.01
pH 2.1 acetate buffer	6.170	0.02
pH 5.5 acetate buffer	6.261	0.03
pH 6.8 phosphate buffer	93.457	0.03

aMean of three determinations; S.D.: standard deviation.