Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Anesthesiology
Volume 2015, Article ID 834168, 4 pages
http://dx.doi.org/10.1155/2015/834168
Case Report

Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease

1Anesthesiology, Morgan Stanley Children’s Hospital at Columbia University, New York, NY 10032, USA
2Anesthesiology, New York University Langone Medical Center, New York, NY 10016, USA
3Anesthesiology and Pediatrics, Morgan Stanley Children’s Hospital at Columbia University, New York, NY 10032, USA

Received 29 September 2015; Accepted 29 November 2015

Academic Editor: Jian-jun Yang

Copyright © 2015 Jennifer Busse et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. U. Forinder, C. Löf, and J. Winiarski, “Quality of life and health in children following allogeneic SCT,” Bone Marrow Transplantation, vol. 36, no. 2, pp. 171–176, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Akpek, W. Chinratanalab, L. A. Lee et al., “Gastrointestinal involvement in chronic graft-versus-host disease: a clinicopathologic study,” Biology of Blood and Marrow Transplantation, vol. 9, no. 1, pp. 46–51, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Mercadante, E. Arcuri, W. Tirelli, and A. Casuccio, “Analgesic effect of intravenous ketamine in cancer patients on morphine therapy: a randomized, controlled, double-blind, crossover, double-dose study,” Journal of Pain and Symptom Management, vol. 20, no. 4, pp. 246–252, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Yin, R. A. Mufson, R. Wang, and Y. Shi, “Fas-mediated cell death promoted by opioids,” Nature, vol. 397, article 218, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. R. F. Bell, C. Eccleston, and E. Kalso, “Ketamine as adjuvant to opioids for cancer pain. A qualitative systematic review,” Journal of Pain and Symptom Management, vol. 26, no. 3, pp. 867–875, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. R. F. Bell, “Ketamine for chronic non-cancer pain,” Pain, vol. 141, no. 3, pp. 210–214, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Okon, “Ketamine: an introduction for the pain and palliative medicine physician,” Pain Physician, vol. 10, no. 3, pp. 493–500, 2007. View at Google Scholar · View at Scopus
  8. A. K. Mehta, S. Halder, N. Khanna, O. P. Tandon, and K. K. Sharma, “Antagonism of stimulation-produced analgesia by naloxone and N-methyl-D-aspartate: role of opioid and N-methyl-D-aspartate receptors,” Human and Experimental Toxicology, vol. 31, no. 1, pp. 51–56, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Gupta, L. A. Devi, and I. Gomes, “Potentiation of μ-opioid receptor-mediated signaling by ketamine,” Journal of Neurochemistry, vol. 119, no. 2, pp. 294–302, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Latremoliere and C. J. Woolf, “Central sensitization: a generator of pain hypersensitivity by central neural plasticity,” Journal of Pain, vol. 10, no. 9, pp. 895–926, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Luginbühl, A. Gerber, T. W. Schnider, S. Petersen-Felix, L. Arendt-Nielsen, and M. Curatolo, “Modulation of remifentanil-induced analgesia, hyperalgesia, and tolerance by small-dose ketamine in humans,” Anesthesia and Analgesia, vol. 96, no. 3, pp. 726–732, 2003. View at Google Scholar · View at Scopus
  12. A. L. Bredlau, R. Thakur, D. N. Korones, and R. H. Dworkin, “Ketamine for pain in adults and children with cancer: a systematic review and synthesis of the literature,” Pain Medicine, vol. 14, no. 10, pp. 1505–1517, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. A.-L. Bredlau, M. P. McDermott, H. R. Adams et al., “Oral ketamine for children with chronic pain: a pilot phase 1 study,” Journal of Pediatrics, vol. 163, no. 1, pp. 194–200, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. M. J. Sigtermans, J. J. van Hilten, M. C. R. Bauer et al., “Ketamine produces effective and long-term pain relief in patients with complex regional pain syndrome type 1,” Pain, vol. 145, no. 3, pp. 304–311, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. R. J. Schwartzman, G. M. Alexander, J. R. Grothusen, T. Paylor, E. Reichenberger, and M. Perreault, “Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: a double-blind placebo controlled study,” Pain, vol. 147, no. 1–3, pp. 107–115, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. G. R. Lauretti, I. C. Lima, M. P. Reis, W. A. Prado, and N. L. Pereira, “Oral ketamine and transdermal nitroglycerin as analgesic adjuvants to oral morphine therapy for cancer pain,” Anesthesiology, vol. 90, no. 6, pp. 1528–1533, 1999. View at Google Scholar
  17. G. R. Lauretti, J. M. A. Gomes, M. P. Reis, and N. L. Pereira, “Low doses of epidural ketamine or neostigmine, but not midazolam, improve morphine analgesia in epidural terminal cancer pain therapy,” Journal of Clinical Anesthesia, vol. 11, no. 8, pp. 663–668, 1999. View at Publisher · View at Google Scholar · View at Scopus
  18. J. C. Finkel, S. R. Pestieau, and Z. M. N. Quezado, “Ketamine as an adjuvant for treatment of cancer pain in children and adolescents,” Journal of Pain, vol. 8, no. 6, pp. 515–521, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Conway, N. White, C. S. Jean, W. T. Zempsky, and K. Steven, “Use of continuous intravenous ketamine for end-stage cancer pain in children,” Journal of Pediatric Oncology Nursing, vol. 26, no. 2, pp. 100–106, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. B. C. H. Tsui, D. Davies, S. Desai, and S. Malherbe, “Intravenous ketamine infusion as an adjuvant to morphine in a 2-year-old with severe cancer pain from metastatic neuroblastoma,” Journal of Pediatric Hematology/Oncology, vol. 26, no. 10, pp. 678–680, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. M. I. Blonk, B. G. Koder, P. M. van den Bemt, and F. J. P. M. Huygen, “Use of oral ketamine in chronic pain management: a review,” European Journal of Pain, vol. 14, no. 5, pp. 466–472, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Hardy, S. Quinn, B. Fazekas et al., “Randomized, double-blind, placebo-controlled study to assess the efficacy and toxicity of subcutaneous ketamine in the management of cancer pain,” Journal of Clinical Oncology, vol. 30, no. 29, pp. 3611–3617, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. I. M. Noppers, M. Niesters, L. P. H. J. Aarts et al., “Drug-induced liver injury following a repeated course of ketamine treatment for chronic pain in CRPS type 1 patients: a report of 3 cases,” Pain, vol. 152, no. 9, pp. 2173–2178, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Klepstad, P. Borchgrevink, B. Hval, S. Flaat, and S. Kaasa, “Long-term treatment with ketamine in a 12-year-old girl with severe neuropathic pain caused by a cervical spinal tumor,” Journal of Pediatric Hematology/Oncology, vol. 23, no. 9, pp. 616–619, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. D. G. Critchlow, “A case of ketamine dependence with discontinuation symptoms,” Addiction, vol. 101, no. 8, pp. 1212–1213, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. J. X. Liu, E. Zerbo, and S. Ross, “Intensive ketamine use for multiple years: a case report,” The American Journal on Addictions, vol. 24, no. 1, pp. 7–9, 2015. View at Publisher · View at Google Scholar
  27. J. L. Walgren, M. A. Carfagna, D. Koger, M. Sgro, and M. J. Kallman, “Withdrawal assessment following subchronic oral ketamine administration in cynomolgus macaques,” Drug Development Research, vol. 75, no. 3, pp. 162–171, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Błachut, K. Sołowiów, A. Janus et al., “A case of ketamine dependence,” Psychiatria Polska, vol. 43, no. 5, pp. 593–599, 2009. View at Google Scholar · View at Scopus
  29. A. C. Mitchell, “Generalized hyperalgesia and allodynia following abrupt cessation of subcutaneous ketamine infusion,” Palliative Medicine, vol. 13, no. 5, pp. 427–428, 1999. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Stagg and J. Galipeau, “Mechanisms of immune modulation by mesenchymal stromal cells and clinical translation,” Current Molecular Medicine, vol. 13, no. 5, pp. 856–867, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. C. B. Berde and N. F. Sethna, “Analgesics for the treatment of pain in children,” The New England Journal of Medicine, vol. 347, no. 14, pp. 1094–1103, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. G. K. Aghajanian and C. P. VanderMaelen, “Alpha 2-adrenoceptor-mediated hyperpolarization of locus coeruleus neurons: intracellular studies in vivo,” Science, vol. 215, no. 4538, pp. 1394–1396, 1982. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Kushikata, H. Yoshida, M. Kudo, T. Kudo, T. Kudo, and K. Hirota, “Role of coerulean noradrenergic neurones in general anaesthesia in rats,” British Journal of Anaesthesia, vol. 107, no. 6, pp. 924–929, 2011. View at Publisher · View at Google Scholar · View at Scopus