Case Reports in Cardiology

Case Reports in Cardiology / 2015 / Article

Case Report | Open Access

Volume 2015 |Article ID 375089 |

Fahad Almehmadi, Mark Davis, Sheldon M. Singh, "Mobile Intracardiac Mass after Inguinal Hernia Repair: An Unresolved Treatment Dilemma", Case Reports in Cardiology, vol. 2015, Article ID 375089, 4 pages, 2015.

Mobile Intracardiac Mass after Inguinal Hernia Repair: An Unresolved Treatment Dilemma

Academic Editor: Mohammad R. Movahed
Received09 Mar 2015
Revised02 Jun 2015
Accepted08 Jun 2015
Published16 Aug 2015


Right heart thrombi (RHT) are rare but well-described entity in literature. Their isolation has been considered as confirmatory for the diagnosis of venous thromboembolism (VTE). Even though their isolation aids the diagnosis, physicians are faced with a difficult management dilemma giving the paucity of data to support any treatment decision. We present a case of RHT in an 81-year-old man who presented to hospital with a large mobile right heart thrombus in transit seen on transthoracic echocardiogram (TTE). He was successfully treated with anticoagulation alone. This case highlights the importance of TTE in establishing the diagnosis and describes the interplay of factors influencing treatment decision.

1. Introduction

Right heart thrombi (RHT) are rare manifestation of venous thromboembolism (VTE); their presence is considered a marker for higher clot burden and worse outcome [13]. Guidelines for management of VTE are well established [4]. But little is known about the optimum treatment strategy for RHT.

We present a case of right heart thrombi discovered on TTE emphasizing the utility of TTE in the setting of VTE. We aim also to describe the interplay of multiple clinical factors that may aid in treatment decision-making.

2. Case Presentation

An 81-year-old man presented with syncope 3 days after inguinal hernia repair. His past medical history was significant for a deep venous thrombosis that was diagnosed 2 months earlier. Electrocardiogram on presentation demonstrated sinus tachycardia with a S1Q3T3 pattern (Figure 1). Pulmonary embolism was suspected. Given a low creatinine clearance and a documented contrast allergy contrast CT angiography was not possible. As such, a transthoracic echocardiogram was performed demonstrating a dilated, hypokinetic right ventricle with preservation of apical contractile function (Supplemental Video in the Supplementary Material available online at which has been reported to be consistent with a pulmonary embolism (McConnell’s sign). Additionally a mobile serpiginous intracardiac mass straddling the tricuspid valve was present representing a thrombus in transit (Figures 2(a) and 2(b), Supplemental Video). Multiple bilateral large perfusion defects were observed in a ventilation perfusion scan confirming pulmonary emboli. Bilateral lower extremity deep venous thromboses were also present with leg Doppler evaluation. Fibrinolysis was contemplated given the presence of a large clot burden, right ventricular compromise, and presentation with syncope. However, given the increased bleeding risk due to age and renal dysfunction, conservative therapy with intense anticoagulation was initiated. During the course of therapy the patient experienced a brief episode of dyspnea and hypoxia presumed to be related to additional pulmonary embolism from the right heart thrombus given the fact that the thrombus visualized within the right heart initially was no longer present subsequent to this event. The patient remained hemodynamically stable with preserved oxygenation during his stay in the coronary care unit. He was subsequently discharged home.

3. Discussion

Right heart thrombi (RHT) can be one of many potential causes of a right heart mass including congenital structures (e.g., Chiari network, persistent Eustachian valve, and atrial septal aneurysm) and acquired causes (e.g., leads, vegetation, or tumors) [5, 6]. Clinical history and imaging will aid in diagnosis.

This case highlights the value of echocardiography with suspected pulmonary embolism. Although typical echocardiographic findings provide indirect evidence of pulmonary embolism, in the absence of prior cardiopulmonary disease these findings can be specific [7, 8]. Right heart thrombus (RHT) in transit has been reported in 4–10% of cases of pulmonary embolism [9]. This finding confirms the diagnosis, indicates a higher clot burden, worse pulmonary hemodynamics, and functional class, and is associated with a 10-fold higher mortality than that of isolated pulmonary embolism [13].

Treatment of RHT represents a management dilemma, given the absence of clear consensus treatment guidelines. Indeed, the need for appropriate therapy is most evident by the high mortality observed in the first 24 hours and an overall mortality in untreated patients approaching 100% [3, 5].

Management strategies of varying risk have been proposed including pharmacological therapy with either intensive anticoagulation or thrombolysis and invasive therapy with either a catheter-based or surgical embolectomy. Comparative effectiveness studies evaluating these strategies have been limited by their small sample size and lack of randomization, both of which do not allow for a true understanding of the risks and benefits of each approach. For example, Finlayson described 38 cases of right heart thrombi where a similar and high (20–62%) in-hospital mortality was present regardless of the treatment modality used [5]. In contrast, Ryu et al. suggested that thrombolysis may have a mortality benefit over other therapeutic approaches with a mortality rate reported at 11% compared to 23% and 28% observed in patients treated with surgical embolectomy and anticoagulation, respectively [3].

Thrombolytic therapy has been advocated as the first treatment modality [1, 3, 5, 1013] due to its widespread availability in clinical practice and its ability to hasten thrombus breakdown thereby lowering the overall thrombus burden and improve right and left ventricular hemodynamics [5, 10]. Successful thrombolysis has been reported with both slow and rapid infusion of Tissue Plasminogen Activator (tPA) [14]. Thrombolysis, however, does have the limitation of increased risk of bleeding, repeat embolization with subsequent sudden death, and chronic thromboembolic pulmonary hypertension [12, 15]. Surgical embolectomy has been advocated as a rescue therapy [12, 15, 16]. Surgery has its inherent risks including the need to transport to a more experienced facility, anesthesia risk, and the inability to clear distal pulmonary circulation emboli [15, 17]. Despite this, surgery may be the only option in a critically ill patient [1820].

Catheter aspiration thrombectomy has also been used with success in few reported cases [17, 21]. This modality may only be feasible in few highly specialized centers. Even when it is available, gaining a safe access to the right atrium can be very challenging in the setting of VTE.

Anticoagulation is not advocated as a sole therapy [1, 3, 5, 22]. However, as demonstrated in the case, other clinical factors may prevent patients from receiving more aggressive therapy. As such, this approach may be the only one available to patients.

Given the limitations of each available therapy and lack of consensus on the management of patients with RHT, a personalized approach accounting for patient and institutional factors must be adopted for each patient.


RHT:Right heart thrombi
VTE:Venous thromboembolism.

Conflict of Interests

The authors declare that there is no conflict of interests regarding the publication of this paper.

Supplementary Materials

Apical 4 chamber and right ventricular inflow views on transthoracic echocardiogram showing the mobile intracardiac thrombus protruding through the tricuspid valve.

  1. Supplementary Material


  1. V. Agarwal, N. Nalluri, M. A. Shariff et al., “Large embolus in transit—an unresolved therapeutic dilemma (case report and review of literature),” Heart & Lung: The Journal of Critical Care, vol. 43, no. 2, pp. 152–154, 2014. View at: Publisher Site | Google Scholar
  2. F. Casazza, C. Becattini, E. Guglielmelli et al., “Prognostic significance of free-floating right heart thromboemboli in acute pulmonary embolism: results from the Italian pulmonary embolism registry,” Thrombosis and Haemostasis, vol. 111, no. 1, pp. 53–57, 2014. View at: Publisher Site | Google Scholar
  3. P. S. Rose, N. M. Punjabi, and D. B. Pearse, “Treatment of right heart thromboemboli,” Chest, vol. 121, no. 3, pp. 806–814, 2002. View at: Publisher Site | Google Scholar
  4. C. Kearon, E. A. Akl, A. J. Comerota et al., “Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines,” Chest, vol. 141, pp. e419S–e494S, 2012. View at: Google Scholar
  5. L. Chartier, J. Béra, M. Delomez et al., “Free-floating thrombi in the right heart: diagnosis, management, and prognostic indexes in 38 consecutive patients,” Circulation, vol. 99, no. 21, pp. 2779–2783, 1999. View at: Publisher Site | Google Scholar
  6. S. Demirkol, F. G. Yesil, U. Bozlar, M. Unlu, S. Balta, and M. A. Sahin, “Multimodality imaging of a right atrial thrombus obliterating inferior vena cava,” Echocardiography, vol. 30, no. 5, pp. E145–E147, 2013. View at: Publisher Site | Google Scholar
  7. J. H. Ryu, P. A. Pellikka, D. A. Froehling, S. G. Peters, and G. L. Aughenbaugh, “Saddle pulmonary embolism diagnosed by CT angiography: frequency, clinical features and outcome,” Respiratory Medicine, vol. 101, no. 7, pp. 1537–1542, 2007. View at: Publisher Site | Google Scholar
  8. R. P. Sosland and K. Gupta, “Images in cardiovascular medicine: McConnell's sign,” Circulation, vol. 118, no. 15, pp. e517–e518, 2008. View at: Publisher Site | Google Scholar
  9. G. N. Finlayson, “Right heart thrombi: consider the cause,” The Canadian Journal of Cardiology, vol. 24, article 888, 2008. View at: Google Scholar
  10. R. K. Shankarappa, R. S. Math, S. Papaiah, Y. M. Channabasappa, S. Karur, and M. C. Nanjappa, “Free floating right atrial thrombus with massive pulmonary embolism: near catastrophic course following thrombolytic therapy,” Indian Heart Journal, vol. 65, no. 4, pp. 460–463, 2013. View at: Publisher Site | Google Scholar
  11. Y. Kato, Y. Fukuda, S.-I. Miura, and K. Saku, “Right heart thrombosis with pulmonary embolism,” Internal Medicine, vol. 52, no. 15, pp. 1745–1746, 2013. View at: Publisher Site | Google Scholar
  12. Y. P. Yoo and K.-W. Kang, “Successful embolectomy of a migrated thrombolytic free-floating massive thrombus resulting in a pulmonary thromboembolism,” Journal of Cardiovascular Ultrasound, vol. 21, no. 1, pp. 37–39, 2013. View at: Publisher Site | Google Scholar
  13. Ö. Şatiroğlu, M. Durakoğlugil, Y. Uğurlu et al., “Successful thrombolysis using recombinant tissue plasminogen activator in cases of severe pulmonary embolism with mobile thrombi in the right atrium,” Interventional Medicine & Applied Science, vol. 6, no. 2, pp. 89–92, 2014. View at: Publisher Site | Google Scholar
  14. R. Arsanjani, S. Goldman, M. P. Habib, and M. R. Movahed, “Modified thrombolytic therapy for massive pulmonary emboli,” The American Journal of Medicine, vol. 124, no. 8, pp. e7–e8, 2011. View at: Publisher Site | Google Scholar
  15. K. Hisatomi, T. Yamada, and D. Onohara, “Surgical embolectomy of a floating right heart thrombus and acute massive pulmonary embolism: report of a case,” Annals of Thoracic and Cardiovascular Surgery, vol. 19, no. 4, pp. 316–319, 2013. View at: Publisher Site | Google Scholar
  16. G. M. Lohrmann, F. Peters, S. van Riet, and M. R. Essop, “Double trouble—a case report of mobile right atrial thrombus in the setting of acute pulmonary thromboembolism,” Heart, Lung & Circulation, vol. 23, no. 10, pp. e214–e216, 2014. View at: Publisher Site | Google Scholar
  17. T. Momose, T. Morita, and T. Misawa, “Percutaneous treatment of a free-floating thrombus in the right atrium of a patient with pulmonary embolism and acute myocarditis,” Cardiovascular Intervention and Therapeutics, vol. 28, no. 2, pp. 188–192, 2013. View at: Publisher Site | Google Scholar
  18. R. Yuan, “Neither here nor there: impending paradoxical embolism,” The American Journal of Medicine, vol. 127, no. 12, pp. 1169–1171, 2014. View at: Publisher Site | Google Scholar
  19. A. Kessel-Schaefer, M. Lefkovits, M. J. Zellweger et al., “Migrating thrombus trapped in a patent foramen ovale,” Circulation, vol. 103, no. 14, article 1928, 2001. View at: Publisher Site | Google Scholar
  20. T. Theologou, P. Tewari, K. Pointon, and I. M. Mitchell, “Pulmonary thromboembolism with floating thrombus trapped in patent foramen ovale,” Annals of Thoracic Surgery, vol. 84, no. 6, pp. 2104–2106, 2007. View at: Publisher Site | Google Scholar
  21. J. Mukharji and J. E. Peterson, “Percutaneous removal of a large mobile right atrial thrombus using a basket retrieval device,” Catheterization and Cardiovascular Interventions, vol. 51, no. 4, pp. 479–482, 2000. View at: Publisher Site | Google Scholar
  22. H. Akilli, E. E. Gül, A. Aribaş, K. Özdemir, M. Kayrak, and H. I. Erdogan, “Management of right heart thrombi associated with acute pulmonary embolism: a retrospective, single-center experience,” Anadolu Kardiyoloji Dergisi, vol. 13, no. 6, pp. 528–533, 2013. View at: Publisher Site | Google Scholar

Copyright © 2015 Fahad Almehmadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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