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Case Reports in Cardiology
Volume 2017 (2017), Article ID 9473917, 4 pages
Case Report

Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses

1Department of Cardiology, Japanese Red Cross Ashikaga Hospital, Ashikaga, Japan
2Department of Neurology, Japanese Red Cross Ashikaga Hospital, Ashikaga, Japan
3Department of General Internal Medicine, Hiroshima-Nishi Medical Center, Ohtake, Japan
4Department of Internal Medicine, Asahi School of Dentistry University, Mizuho, Japan
5Department of Gastroenterology, Japanese Red Cross Ashikaga Hospital, Ashikaga, Japan
6Department of Cardiology, Jichi Medical University, Shimotsuke, Japan

Correspondence should be addressed to Toshiki Kuno

Received 3 March 2017; Accepted 4 May 2017; Published 23 May 2017

Academic Editor: Nurten Sayar

Copyright © 2017 Toshiki Kuno et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report a case with 46-year-old man diagnosed with mitochondrial cardiomyopathy in the dilated phase of hypertrophic cardiomyopathy. Since cardiac magnetic resonance imaging, beta-methyl-p--iodophenyl-pentadecanoic myocardial scintigraphy, and positron emission tomography/computed tomography revealed no remarkable findings, we performed electron microscopic examination, which aided in diagnosing mitochondrial cardiomyopathy. Muscle biopsy was also compatible with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes and DNA analysis also concluded it. Since muscle biopsy is less invasive for patients compared to endomyocardial biopsy, cardiologists need to consider it. The diagnosis of mitochondrial cardiomyopathy is helpful because it is a genetic condition and also for consideration of device therapy, as well as management for acute crisis.