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Case Reports in Critical Care
Volume 2016 (2016), Article ID 7379829, 4 pages
Case Report

A Curious Case of Acute Respiratory Failure: Is It Antisynthetase Syndrome?

1University of Illinois at Chicago, Chicago, IL 60612, USA
2Internal Medicine, Mount Sinai Hospital, Chicago, IL 60608, USA
3Rheumatology, Mount Sinai Hospital, Chicago, IL 60608, USA
4Pulmonary & Critical Care Medicine, Mount Sinai Hospital, Chicago, IL 60608, USA

Received 17 January 2016; Revised 7 June 2016; Accepted 7 June 2016

Academic Editor: Chiara Lazzeri

Copyright © 2016 Gurveen Malhotra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Antisynthetase (AS) syndrome is a major subgroup of inflammatory myopathies seen in a minority of patients with dermatomyositis and polymyositis. Although it is usually associated with elevated creatine phosphokinase level, some patients may have amyopathic dermatomyositis (ADM) like presentation with predominant skin involvement. Interstitial lung disease (ILD) is the main pulmonary manifestation and may be severe thereby determining the prognosis. It may rarely present with a very aggressive course resulting in acute respiratory distress syndrome (ARDS). We report a case of a 43-year-old male who presented with nonresolving pneumonia who was eventually diagnosed to have ADM through a skin biopsy without any muscle weakness. ADM may be associated with rapidly progressive course of interstitial lung disease (ADM-ILD) which is associated with high mortality. Differentiation between ADM-ILD and AS syndrome may be difficult in the absence of positive serology and clinical presentation may help in clinching the diagnosis.