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Case Reports in Critical Care
Volume 2016, Article ID 8531591, 6 pages
http://dx.doi.org/10.1155/2016/8531591
Case Report

Fatal Nonhepatic Hyperammonemia in ICU Setting: A Rare but Serious Complication following Bariatric Surgery

1Department of Internal Medicine, Wyckoff Heights Medical Center, Brooklyn, NY 11237, USA
2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Wyckoff Heights Medical Center, Brooklyn, NY 11237, USA
3Department of Medical Education, Wyckoff Heights Medical Center, Brooklyn, NY 11237, USA

Received 3 January 2016; Accepted 15 March 2016

Academic Editor: Gerhard Pichler

Copyright © 2016 Gyanendra Acharya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. K. Dhiman and Y. K. Chawla, “Minimal hepatic encephalopathy: time to recognise and treat,” Tropical Gastroenterology, vol. 29, no. 1, pp. 6–12, 2008. View at Google Scholar · View at Scopus
  2. D. Shawcross and R. Jalan, “The pathophysiologic basis of hepatic encephalopathy: central role for ammonia and inflammation,” Cellular and Molecular Life Sciences, vol. 62, no. 19-20, pp. 2295–2304, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Nott, T. J. Price, K. Pittman, K. Patterson, and J. Fletcher, “Hyperammonemia encephalopathy: an important cause of neurological deterioration following chemotherapy,” Leukemia and Lymphoma, vol. 48, no. 9, pp. 1702–1711, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Albersen, S. Joniau, H. Van Poppel, P.-J. Cuyle, D. C. Knockaert, and W. Meersseman, “Urea-splitting urinary tract infection contributing to hyperammonemic encephalopathy,” Nature Clinical Practice Urology, vol. 4, no. 8, pp. 455–458, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. R. E. Grazer, J. M. Sutton, S. Friedstrom, and F. D. McBarron, “Hyperammonemic encephalopathy due to essential amino acid hyperalimentation,” Archives of Internal Medicine, vol. 144, no. 11, pp. 2278–2279, 1984. View at Publisher · View at Google Scholar · View at Scopus
  6. D. M. Felig, S. W. Brusilow, and J. L. Boyer, “Hyperammonemic coma due to parenteral nutrition in a woman with heterozygous ornithine transcarbamylase deficiency,” Gastroenterology, vol. 109, no. 1, pp. 282–284, 1995. View at Publisher · View at Google Scholar · View at Scopus
  7. D. G. Vossler, A. J. Wilensky, D. F. Cawthon et al., “Serum and CSF glutamine levels in valproate-related hyperammonemic encephalopathy,” Epilepsia, vol. 43, no. 2, pp. 154–159, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. B. N. Limketkai and S. D. Zucker, “Hyperammonemic encephalopathy caused by carnitine deficiency,” Journal of General Internal Medicine, vol. 23, no. 2, pp. 210–213, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. H. O. de Baulny, A. Slama, G. Touati, D. M. Turnbull, M. Pourfarzam, and M. Brivet, “Neonatal hyperammonemia caused by a defect of carnitine-acylcarnitine translocase,” The Journal of Pediatrics, vol. 127, no. 5, pp. 723–728, 1995. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Longo, C. A. di San Filippo, and M. Pasquali, “Disorders of carnitine transport and the carnitine cycle,” American Journal of Medical Genetics—Seminars in Medical Genetics, vol. 142, no. 2, pp. 77–85, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. C. A. Stanley, “New genetic defects in mitochondrial fatty acid oxidation and carnitine deficiency,” Advances in Pediatrics, vol. 34, pp. 59–88, 1986. View at Google Scholar
  12. J. M. Kwon and K. E. D'Aco, “Clinical neurogenetics: neurologic presentations of metabolic disorders,” Neurologic Clinics, vol. 31, no. 4, pp. 1031–1050, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. J. N. Labuzetta, J. Z. Yao, D. L. Bourque, and J. Zivin, “Adult nonhepatic hyperammonemia: a case report and differential diagnosis,” American Journal of Medicine, vol. 123, no. 10, pp. 885–891, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. O. Braissant, “Current concepts in the pathogenesis of urea cycle disorders,” Molecular Genetics and Metabolism, vol. 100, supplement 1, pp. S3–S12, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. K. R. Bergmann, J. McCabe, T. R. Smith, D. J. Guillaume, K. Sarafoglou, and S. Gupta, “Late-onset ornithine transcarbamylase deficiency: treatment and outcome of hyperammonemic crisis,” Pediatrics, vol. 133, no. 4, pp. e1072–e1076, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Z. Fenves, O. A. Shchelochkov, and A. Mehta, “Hyperammonemic syndrome after Roux-en-Y gastric bypass,” Obesity, vol. 23, no. 4, pp. 746–749, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. W. T. Hu, O. H. Kantarci, J. L. Merritt II et al., “Ornithine transcarbamylase deficiency presenting as encephalopathy during adulthood following bariatric surgery,” Archives of Neurology, vol. 64, no. 1, pp. 126–128, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Estrella, G. Yee, B. Wilcken, M. Tchan, and M. Talbot, “Hyperammonemic encephalopathy complicating bariatric surgery: a case study and review of the literature,” Surgery for Obesity and Related Diseases, vol. 10, no. 3, pp. e35–e38, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. L. C. Kuo, W. N. Lipscomb, and E. R. Kantrowitz, “Zn(II)-induced cooperativity of Escherichia coli ornithine transcarbamoylase,” Proceedings of the National Academy of Sciences of the United States of America, vol. 79, no. 7 I, pp. 2250–2254, 1982. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Aquilio, R. Spagnoli, D. Riggio, and S. Seri, “Effects of zinc on hepatic ornithine transcarbamylase (OTC) activity,” Journal of Trace Elements and Electrolytes in Health and Disease, vol. 7, no. 4, pp. 240–241, 1993. View at Google Scholar · View at Scopus
  21. C. L. Pridmore, J. T. R. Clarke, and S. Blaser, “Ornithine transcarbamylase deficiency in females: an often overlooked cause of treatable encephalopathy,” Journal of Child Neurology, vol. 10, no. 5, pp. 369–374, 1995. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Yamaguchi, L. L. Brailey, H. Morizono, A. E. Bale, and M. Tuchman, “Mutations and polymorphisms in the human ornithine transcarbamylase (OTC) gene,” Human Mutation, vol. 27, no. 7, pp. 626–632, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. A. S. Clay and B. E. Hainline, “Hyperammonemia in the ICU,” Chest, vol. 132, no. 4, pp. 1368–1378, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. V. Walker, “Severe hyperammonaemia in adults not explained by liver disease,” Annals of Clinical Biochemistry, vol. 49, no. 3, pp. 214–228, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. E. Chousleb, S. Patel, S. Szomstein, and R. Rosenthal, “Reasons and operative outcomes after reversal of gastric bypass and jejunoileal bypass,” Obesity Surgery, vol. 22, no. 10, pp. 1611–1616, 2012. View at Publisher · View at Google Scholar · View at Scopus