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Case Reports in Critical Care
Volume 2016, Article ID 9157393, 6 pages
http://dx.doi.org/10.1155/2016/9157393
Case Report

Ethylene Glycol Poisoning: An Unusual Cause of Altered Mental Status and the Lessons Learned from Management of the Disease in the Acute Setting

Detroit Medical Center/Wayne State University, Detroit, MI, USA

Received 22 April 2016; Revised 24 August 2016; Accepted 20 September 2016

Academic Editor: Ricardo Oliveira

Copyright © 2016 R. Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. http://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750031.html
  2. http://www.cnn.com/2007/LAW/01/05/black.widow/index.html
  3. Safety Officer in Physical Chemistry, Safety (MSDS) Data for Ethylene Glycol, Oxford University, Oxford, UK, 2009.
  4. A. D. Fraser, “Clinical toxicologic implications of ethylene glycol and glycolic acid poisoning,” Therapeutic Drug Monitoring, vol. 24, no. 2, pp. 232–238, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Brent, K. McMartin, S. Phillips et al., “Fomepizole for the treatment of ethylene glycol poisoning,” The New England Journal of Medicine, vol. 340, no. 11, pp. 832–838, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Jacobsen, “New treatment for ethylene glycol poisoning,” The New England Journal of Medicine, vol. 340, no. 11, pp. 879–881, 1999. View at Publisher · View at Google Scholar
  7. https://aapcc.s3.amazonaws.com/pdfs/annual_reports/2013_NPDS_Annual_Report.pdf
  8. http://www.npis.org/NPISAnnualReport2013-14.pdf
  9. J. A. Kruse, “Methanol and ethylene glycol intoxication,” Critical Care Clinics, vol. 28, no. 4, pp. 661–711, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. V. Poldelski, A. Johnson, S. Wright, V. D. Rosa, and R. A. Zager, “Ethylene glycol-mediated tubular injury: identification of critical metabolites and injury pathways,” American Journal of Kidney Diseases, vol. 38, no. 2, pp. 339–348, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. D. Jacobsen, T. P. Hewlett, R. Webb, S. T. Brown, A. T. Ordinario, and K. E. McMartin, “Ethylene glycol intoxication: evaluation of kinetics and crystalluria,” The American Journal of Medicine, vol. 84, no. 1, pp. 145–152, 1988. View at Publisher · View at Google Scholar · View at Scopus
  12. A. S. Church and M. D. Witting, “Laboratory testing in ethanol, methanol, ethylene glycol, and isopropanol toxicities,” Journal of Emergency Medicine, vol. 15, no. 5, pp. 687–692, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. A. F. Eder, Y. G. Dowdy, J. A. M. Gardiner, B. A. Wolf, and L. M. Shaw, “Serum lactate and lactate dehydrogenase in high concentrations interfere in enzymatic assay of ethylene glycol,” Clinical Chemistry, vol. 42, no. 9, pp. 1489–1491, 1996. View at Google Scholar · View at Scopus
  14. P. A. Gabow, K. Clay, J. B. Sullivan, and R. Lepoff, “Organic acids in ethylene glycol intoxication,” Annals of Internal Medicine, vol. 105, no. 1, pp. 16–20, 1986. View at Publisher · View at Google Scholar · View at Scopus
  15. T. J. Morgan, C. Clark, and A. Clague, “Artifactual elevation of measured plasma L-lactate concentration in the presence of glycolate,” Critical Care Medicine, vol. 27, no. 10, pp. 2177–2179, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. P. G. Brindley, M. S. Butler, G. Cembrowski, and D. N. Brindley, “Falsely elevated point-of-care lactate measurement after ingestion of ethylene glycol,” Canadian Medical Association Journal, vol. 176, no. 8, pp. 1097–1099, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. R. S. Hoffman, M. J. Smilkstein, M. A. Rowland, and L. R. Goldfrank, “Osmol gaps revisited: normal values and limitations,” Journal of Toxicology: Clinical Toxicology, vol. 31, no. 1, pp. 81–93, 1993. View at Publisher · View at Google Scholar · View at Scopus
  18. D. G. Barceloux, E. P. Krenzelok, K. Olson, W. Watson, and H. Miller, “American academy of clinical toxicology practice guidelines on the treatment of ethylene glycol poisoning,” Journal of Toxicology—Clinical Toxicology, vol. 37, no. 5, article 537, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. K. J. Lepik, A. R. Levy, B. G. Sobolev et al., “Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole,” Annals of Emergency Medicine, vol. 53, no. 4, pp. 439.e10–450.e10, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. G. M. Youssef and D. J. Hirsch, “Validation of a method to predict required dialysis time for cases of methanol and ethylene glycol poisoning,” American Journal of Kidney Diseases, vol. 46, no. 3, pp. 509–511, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. D. D. Lung, T. E. Kearney, J. A. Brasiel, and K. R. Olson, “Predictors of death and prolonged renal insufficiency in ethylene glycol poisoning,” Journal of Intensive Care Medicine, vol. 30, no. 5, pp. 270–277, 2015. View at Publisher · View at Google Scholar · View at Scopus