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Case Reports in Critical Care
Volume 2017 (2017), Article ID 4141287, 4 pages
Case Report

Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases

1Department of Medicine, University of CT Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
2Division of Pulmonary-Critical Care Medicine, University of CT Health Center, Farmington, CT 06030, USA

Correspondence should be addressed to Debapriya Datta

Received 1 February 2017; Revised 6 July 2017; Accepted 30 July 2017; Published 11 September 2017

Academic Editor: Ricardo Oliveira

Copyright © 2017 Vivek Alaigh and Debapriya Datta. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardiac arrhythmias, renal failure, and death. TLS is usually seen after the initiation of chemotherapy for hematologic malignancies. TLS occurring spontaneously, without initiation of chemotherapy, is rare and its occurrence in solid tumors is rarer still. We report a case of spontaneous TLS in a patient with leiomyosarcoma of the uterus, with metastasis to lung. Such a case has never been reported before.