Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema in Intubated Patients: Case Series and Literature Review

Table 1

Summary of patient cases.

Patients,	Case	Case	Case
Characteristics
Gender	Female	Male	Male
Age, years	60	52	62
Ethnicity	African American	African American	Caucasian
Duration of ACEI therapy, months	81	36	48
Symptoms	Difficulty breathing and swallowing, shortness of breath, coughing	Chest pain, difficulty swallowing and talking, shortness of breath, sensations of “throat closing,” swelling of tongue, mouth, and eyes	Macroglossia, muffled voice, shortness of breath
Clinical course
Symptom onset to ED presentation	1 week	4 hours	5 hours
ED presentation to intubation, mins	20	“Minutes later”	Immediately
ED presentation to icatibant, hrs	12	11	11
Icatibant administration	After intubation	After intubation	After intubation
Icatibant to first symptom resolution, hrs	20	22	11
Hospital day of extubation	Day 4	Day 5	Day 3
ED presentation to discharge	Day 7	Day 6	Day 5