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Case Reports in Dentistry
Volume 2013, Article ID 315109, 4 pages
http://dx.doi.org/10.1155/2013/315109
Case Report

Multiple Hamartoma Syndrome with Characteristic Oral and Cutaneous Manifestations

1Department of Oral Medicine and Radiology, MS Ramaiah Dental College and Hospital, Bangalore, Karnataka 560010, India
2Department of Oral Pathology, MS Ramaiah Dental College and Hospital, Bangalore, India
3Department of Dentistry, Indiragandhi District Hospital, Mandsaur, Madhya Pradesh 458001, India

Received 18 June 2013; Accepted 12 August 2013

Academic Editors: J. Asaumi, D. W. Boston, T. Lombardi, and E. F. Wright

Copyright © 2013 Prashanthi Chippagiri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. To present a case of Cowden's syndrome and emphasize the importance of continued cancer surveillance in these patients. Cowden syndrome is an inherited autosomal dominant trait with incomplete penetrance and a range of expressivity. It is characterized by multiple hamartomas and neoplasms. Mucocutaneous features include trichilemmomas, oral mucosal papillomatosis, acral keratosis, and palmoplantar keratosis. Here, we report a case of Cowdens syndrome of a 30-year-old female patient who came with a complaint of multiple growths in the oral cavity of a three-month duration. On examination, multiple skin-colored, flat-topped papules over her forehead and right malar bone and multiple papillomatous papules involving all the mucosal surfaces intraorally were observed. This syndrome is associated with the development of several types of malignancies, especially breast carcinoma and thyroid carcinoma, which is why early recognition and regular and vigilant surveillance of individuals with the syndrome are important.