Case Report

Idiopathic Orofacial Granulomatosis with Varied Clinical Presentation

Table 2

Differential diagnosis of orofacial granulomatosis.

DiseaseFeatures different to OFG

Crohn’s diseaseHave illeal and/or rectal disease
SarcoidosisPulmonary, cutaneuos, lacrimal, salivary, neurological, skeletal features
Allergic angioedemaNonpitting oedema of lips, tongue, pharynx, face. History of atopic disease
Miescher’s cheilitisLabial enlargement, similar histopathology to OFG
Melkerson-Rosenthal syndromeLabial enlargement, fissuring of tongue, facial nerve palsy variant of OFG
Cheilitis glandularisLabial enlargement with ulcers. Mild acute and chronic inflammation (without granuloma) within minor salivary glands of lip
TuberculosisRarely lips. Usually contain caseating granuloma