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Case Reports in Dentistry
Volume 2014 (2014), Article ID 413162, 5 pages
http://dx.doi.org/10.1155/2014/413162
Case Report

Numb Chin Syndrome as First Symptom of Diffuse Large B-Cell Lymphoma

1Department of Surgical Sciences, Oral Medicine Section, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy
2Private Practice, Turin, Italy
3Department of Medical Sciences, Section of Pathology, San Giovanni Battista Hospital, Strada Comunale di S. Vito Revigliasco 34, 10133 Torino, Italy
4Oral Medicine Department, Centre for Oral Health Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear NE1 7RU, UK

Received 1 November 2014; Accepted 2 December 2014; Published 16 December 2014

Academic Editor: Yuk-Kwan Chen

Copyright © 2014 Mario Carbone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Numb chin syndrome is a rare sensory neuropathy of the mental nerve characterized by numbness, hypoesthesia, paraesthesia, and very rarely pain. Dental causes, especially iatrogenic ones, maxillofacial trauma, or malignant neoplasm are etiologic factors for this rare syndrome. Many malignant and metastatic neoplasms are causing this syndrome, like primary osteosarcoma, squamous cell carcinoma, and mandibular metastasis of primary carcinoma of breast, lung, thyroid, kidney, prostate, and nasopharynx. Haematological malignancies like acute lymphocytic leukaemia, Hodgkin and non-Hodgkin lymphoma, and myeloma can cause this neuropathy. The authors report a case of a 71-year-old woman in which the numb chin syndrome was the first symptom of the diffuse large B-cell lymphoma, which caused infiltration and reabsorption of the alveolar ridge and lower mandibular cortex. A biopsy of the mass was performed on fragments of tissue collected from the mandibular periosteum, medullary and cortical mandibular bone, and inferior alveolar nerve.