Case Reports in Dentistry

Case Reports in Dentistry / 2015 / Article

Case Report | Open Access

Volume 2015 |Article ID 319231 |

Anju E. Thomas, Seema Kurup, Renju Jose, Cristalle Soman, "Facial Swelling as a Primary Manifestation of Multiple Myeloma", Case Reports in Dentistry, vol. 2015, Article ID 319231, 6 pages, 2015.

Facial Swelling as a Primary Manifestation of Multiple Myeloma

Academic Editor: Indraneel Bhattacharyya
Received19 May 2015
Revised08 Jun 2015
Accepted15 Jun 2015
Published01 Jul 2015


Facial swellings are commonly encountered in the dental office, the cause of which could range from a congenital etiology to an acquired one or it may even be a manifestation of an underlying systemic disease. The clinician must have a thorough knowledge of the various clinical and imaging manifestations and the sites of occurrence of the various conditions to arrive at the appropriate diagnosis. Facial swellings can be classified into different groups which include acute swellings with inflammation, nonprogressive swellings, and slowly or rapidly progressive swellings. The various imaging modalities like CT and MRI are useful for assessing the extent of the swelling as well as evaluating the soft tissue and osseous involvement of the swelling. Multiple myeloma represents clonal proliferation of plasma cells and is a condition in which a facial swelling might be present, though not common. This paper reports a case of a patient with a unilateral facial swelling, which on investigation led to a diagnosis of multiple myeloma.

1. Introduction

Facial swellings are commonly encountered in the dental office and can be a cause of worry to both the patient and the dentist. They may arise due to a wide range of causes ranging from a congenital etiology to an acquired one [1]. A detailed record of the clinical history and physical manifestations are considered as important factors in the evaluation of facial swelling. Recent advances in the field of imaging have enabled the clinician to determine the presence and extent of disease which will also aid in treatment planning. The clinical manifestations of facial swellings may be categorized into four groups: acute swellings with inflammation and nonprogressive, rapidly progressive, and slowly progressive swellings. Acute swellings are seen in lymphadenitis, odontogenic infections, and abscesses. Nonprogressive swellings are suggestive of a congenital anomaly whereas slowly progressive swellings are seen in vascular malformations, haemangioma, and fibrous dysplasia. Rapidly progressive swellings are usually associated with malignancies. This paper reports a case of facial swelling which proved to be the primary manifestation of multiple myeloma.

2. Case History

A 58-year-old female patient presented with a swelling on the left side of face which had evolved over the previous two months. Although the patient was treated with antibiotics, the swelling continued to enlarge to reach its present size. The patient had neither dryness of the mouth nor increased salivation, and the swelling was persistent. The patient did not have any associated fever or paresthesia. She was a diagnosed diabetic patient on oral hypoglycemics for the past 4 years.

On extraoral examination, a diffuse ovoid swelling was seen on the left middle and lower third of the face extending anteroposteriorly from the nasolabial fold to the tragus of the ear and superoinferiorly from the zygomatic arch to two centimeters beneath the lower border of the mandible. Palpation revealed a nontender, noncompressible, and nonfluctuant swelling which was firm to hard in consistency. There was a slight reduction in mouth opening (Figure 1) and the cervical lymph nodes were nonpalpable.

Intraoral examination revealed a fixed prosthesis in relation to the upper left posterior teeth. The skin overlying the swelling and the oral mucosa were unaltered and were of normal color (Figure 2). The clinically considered diagnosis included Sjogren’s syndrome or a parotid gland tumor.

Various hematological tests included routine blood tests and an ANA screen (Table 1) to rule out autoimmune conditions like Sjogren’s syndrome.

Blood parameterValues (SI unit)Reference range

RBC4.29 1012/L4.0–5.2 1012/L
Total 7.0 109/L4.0–10.0 109/L
 Platelets2.98 105/L1.5–4.5 105/L
 Haemoglobin12.3 g/dL12.2–18.1 g/dL
 ESR64 mm/hr8.0–20.0 mm/hr

An orthopantomograph (OPG) revealed an extensive osteolytic lesion with ill-defined margins involving the left mandibular ramus, body, and coronoid with multiple radiolucent lesions and altered trabecular patterns in the right mandibular ramus, body, and condylar region (Figure 3). Ultrasonography revealed a hypoechoic solid lesion anterior to the superficial lobe of left parotid. FNAC revealed smears with low cellularity and aggregates of binucleated and multinucleated plasma cells.

Contrast enhanced CT showed an expansile lytic and destructive lesion in the left ramus of the mandible with associated soft tissue component and a few enlarged lymph nodes in level 3 on the left side. A lytic lesion was noted in the left frontal bone as well as the right costochondral joint of the second rib (Figures 4 and 5). The radiological differential diagnoses considered were metastatic carcinoma or multiple myeloma taking into account the age of the patient and the ragged margin of the lesion.

Based on the extensive skeletal involvement and the FNAC report, a bone marrow biopsy was done to assess if the patient had multiple myeloma. The aspirate revealed a cellular marrow with hypocellular fragments and poor cellular characteristics and 18% of plasma cells of which few were binucleate. This warranted further confirmatory investigations for multiple myeloma. Biochemical tests for serum calcium and serum creatinine were within normal limits. Serum electrophoresis revealed decreased albumin (3.98 g/dL), increased globulin (4.8 g/dL), and increased beta-2 microglobulin (2.8 g/dL) levels (Table 2). The immunoglobulins in the serum were assessed quantitatively and IgA (3000 mg/dL) was found to be raised and the kappa lambda ratio was found to be 1 : 5 (Table 3).

ParameterValues (SI unit)Reference range

Serum calcium8.4 mg/dL8.5–11.5 mg/dL
Serum creatinine1.37 mg/dL0.84–1.4 mg/dL
Total protein8.75 g/dL6.6–8.3 g/dL
Serum albumin3.98 g/dL3.5–5.2 g/dL
Serum globulin4.8 g/dL2.5–4.0 g/dL

ParameterValue (SI)Reference range

IgG617 mg/dL751–1560 mg/dL
IgM69.3 mg/dL40.0–230.0 mg/dL
IgA3000 mg/dL 82.0–453.0 mg/dL
Kappa free light chain3.7 mg/L3.3–19.4 mg/L
Lambda free light chain16.9 mg/L5.7–26.3 mg/L
Kappa lambda ratio1 : 51 : 1.5
Serum beta-2 microglobulin2.74 mg/L0.8–2.4 mg/L

A final diagnosis of multiple myeloma was made based on the clinical presentations and investigations, which satisfied the revised diagnostic criteria of International Myeloma Working Group (IMWG) [2].

PET CT (Figure 6) was further done to assess the skeletal involvement and this revealed involvement of calvarium, left mandible, and right costochondral joint of second rib. The patient was subjected to both radiotherapy (3000 cGy in 12 fractions over a period of 15 days for the mandibular and parasternal lesion) and chemotherapy with CyBorD (cyclophosphamide, bortezomib, and dexamethasone).

Following 16 weeks of chemotherapy, the patient’s IgA levels normalized and she is currently scheduled for autologous stem cell transplantation.

3. Discussion

The term “multiple myeloma” was introduced by J. Von Rustizky in 1873 when he found eight separate tumors of the bone marrow which he designated as “multiple myeloma.” The first well-documented case of multiple myeloma was reported by Samuel Solley in 1844 [3].

Multiple myeloma is a malignant disease characterized by multifocal proliferation of atypical plasma cells and by the presence in the serum of monoclonal gamma globulins, often referred to as “M” or myeloma proteins [4, 5]. The disease has a male predilection, with the average age at diagnosis being approximately 60 years [6, 7].

Multiple myeloma involves destructive lesions affecting the bone and the patients present with persistent pain in the bone, especially in the affected areas with a history of recurrent infection, fever, fatigue, and multisystem involvement [8, 9].

In our case, the patient was a fifty-eight-year-old female with manifestations in the maxillofacial region. Primary manifestation in the maxillofacial region, though not common, usually manifests as pain, swelling, paresthesia, mobility of tooth, hemorrhage, and pathological fractures [10, 11]. Bruce and Royer [12] have reported a prevalence rate of 28.8% (17 of 59 total cases) in their study while Epstein et al. [13] reported that 14.1% of 783 multiple myeloma cases had oral manifestations. Studies conducted by Lambertenghi-Deliliers et al. showed mandibular jaw involvement in all the 193 cases examined [14].

In the present case, the patient had a swelling on the left side of face which was not associated with pain, paresthesia, or mobility or displacement of the teeth.

Radiographic examinations usually reveal osteolytic lesions with irregular, noncorticated margins and multiple punched out radiolucencies with altered trabecular pattern which was seen in the present case too [15]. The osteolytic lesions have a predilection for the mandible due to the lower amount of hemopoietic marrow in the mandible and are attributed to a lymphokine called “osteoclast activating factor” [16]. Witt et al. reported that 15.6% of patients diagnosed with multiple myeloma had osteolytic lesions in mandible which were asymptomatic and 46.7% had skull manifestations [17].

The diagnosis of multiple myeloma in our case was established by a multidisciplinary diagnostic protocol involving routine investigations of both serum and urine followed by quantification of immunoglobulins. This was accompanied by cytological examination of bone marrow aspirate and a detailed radiological survey in the form of contrast enhanced CT, PET CT to assess the extent of skeletal involvement. Shah et al. have emphasized the importance of 18F-FDG PET/CT in myeloma patients as it enables detection of unsuspected sites of bone involvement, which upstages the disease [18]. The use of PET in the present case confirmed the extent of bone involvement and helped in the staging of the disease.

The patient was staged as stage 1 as per the International Staging System (ISS) (Table 4) which has a fair prognosis with a median survival time of 6–8 years [19].

StageMedian survival time

Stage 1Serum beta-2 microglobulin is less than 3.5 (mg/L) and the albumin level is 3.5 (g/dL) or greater62 months

Stage 2The beta-2 microglobulin level is between 3.5 and 5.5 (with any albumin level)
The albumin is below 3.5, while the beta-2 microglobulin is less than 3.5
44 months

Stage 3Serum beta-2 microglobulin is 5.5 or greater.29 months

Radiotherapy for the symptomatic lesion followed by chemotherapy is the treatment of choice [20]. The chemotherapeutic agents used in the treatment of multiple myeloma include melphalan, vincristine, cyclophosphamide, doxorubicin, and bendamustine in combination with corticosteroids, immunomodulating agents, or proteasome inhibitors [21]. Radiotherapy followed by a combination of cyclophosphamide, bortezomib, and dexamethasone was used in our case for 16 weeks, after which the immunoglobulin levels normalized.

4. Conclusion

The present case reports maxillofacial swelling as the primary manifestation of multiple myeloma, reinforcing the role of the dentist in identification of systemic conditions contributing to maxillofacial manifestations. This facilitates an early and prompt diagnosis, which in turn affects the treatment and prognosis of the patient.

Conflict of Interests

The authors declare that there is no conflict of interests regarding the publication of this paper.


  1. G. Khanna, Y. Sato, R. J. H. Smith, N. M. Bauman, and J. Nerad, “Causes of facial swelling in pediatric patients: correlation of clinical and radiologic findings,” Radiographics, vol. 26, no. 1, pp. 157–171, 2006. View at: Publisher Site | Google Scholar
  2. V. Rajkumar, M. Dimopoulos, A. Palumbo et al., “International Myeloma working group updated criteria for the diagnosis of multiple myeloma,” The Lancet Oncology, vol. 15, no. 12, pp. e538–e548, 2014. View at: Publisher Site | Google Scholar
  3. J. J. Pisano, R. Coupland, S.-Y. Chen, and A. S. Miller, “Plasmacytoma of the oral cavity and jaws. A clinicopathologic study of 13 cases,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, vol. 83, no. 2, pp. 265–271, 1997. View at: Publisher Site | Google Scholar
  4. K. C. Nau and W. D. Lewis, “Multiple myeloma: diagnosis and treatment,” American Family Physician, vol. 78, no. 7, pp. 853–860, 2008. View at: Google Scholar
  5. X. J. Zhao, J. Sun, Y. D. Wang, and Y. L. Wang, “Maxillary pain is the first indication of the presence of multiple myeloma: a case report,” Molecular and Clinical Oncology, vol. 2, no. 1, pp. 59–64, 2014. View at: Publisher Site | Google Scholar
  6. L. S. S. Pinto, E. B. Campagnoli, J. E. Leon, M. A. Lopes, and J. Jorge, “Maxillary lesion presenting as a first sign of multiple myeloma: case report,” Medicina Oral, Patologia Oral y Cirugia Bucal, vol. 12, no. 5, pp. E344–E347, 2007. View at: Google Scholar
  7. American Cancer Society, Multiple Myeloma Guidelines, American Cancer Society, Atlanta, Ga, USA, 2015.
  8. O. N. Obuekwe, N. N. Nwizu, M. A. Ojo, and P. I. Ugbodaga, “Extramedullary presentation of multiple myeloma in the parotid gland as first evidence of the disease—a review with case report,” The Nigerian Postgraduate Medical Journal, vol. 12, no. 1, pp. 45–48, 2005. View at: Google Scholar
  9. A. V.-L. Segundo, M. F. L. Falcão, R. Correia-Lins Filho, M. S. M. Soares, J. López, and E. C. Küstner, “Multiple myeloma with primary manifestation in the mandible: a case report,” Medicina Oral, Patologia Oral y Cirugia Bucal, vol. 13, no. 4, pp. 232–234, 2008. View at: Google Scholar
  10. D. Lesmes and Z. Laster, “Plasmacytoma in the temporomandibular joint: a case report,” British Journal of Oral and Maxillofacial Surgery, vol. 46, no. 4, pp. 322–324, 2008. View at: Publisher Site | Google Scholar
  11. A. N. C. John and T. A. Ajith, “Intraoral complications associated with multiple myeloma: case reports,” Med-Science, vol. 4, no. 2, pp. 2229–2235, 2014. View at: Google Scholar
  12. K. W. Bruce and R. Q. Royer, “Multiple myeloma occurring in the jaws: a study of 17 cases,” Oral Surgery, Oral Medicine, Oral Pathology, vol. 6, no. 6, pp. 729–744, 1953. View at: Publisher Site | Google Scholar
  13. J. B. Epstein, N. J. S. Voss, and P. Stevenson-Moore, “Maxillofacial manifestations of multiple myeloma. An unusual case and review of the literature,” Oral Surgery, Oral Medicine, Oral Pathology, vol. 57, no. 3, pp. 267–271, 1984. View at: Publisher Site | Google Scholar
  14. G. Lambertenghi-Deliliers, E. Bruno, A. Cortelezzi, L. Fumagalli, and A. Morosini, “Incidence of jaw lesions in 193 patients with multiple myeloma,” Oral Surgery Oral Medicine and Oral Pathology, vol. 65, no. 5, pp. 533–537, 1988. View at: Publisher Site | Google Scholar
  15. M. Amirchaghmaghi, A. Pakfetrat, P. M. Mozafari, and S. Saghafi, “Mandibular swelling as the first manifestation of multiple myeloma,” Iranian Journal of Medical Sciences, vol. 35, no. 4, pp. 331–334, 2010. View at: Google Scholar
  16. M. Jose, A. Balan, K. P. Sharafudeen, N. Kumar, and P. Haris, “Mandibular lesion presenting as the first sign of multiple myeloma—report of two cases,” International Journal of Dental Case Reports, vol. 1, no. 2, pp. 22–28, 2011. View at: Google Scholar
  17. C. Witt, A. C. Borges, K. Klein, and H.-J. Neumann, “Radiographic manifestations of multiple myeloma in the mandible: a retrospective study of 77 patients,” Journal of Oral and Maxillofacial Surgery, vol. 55, no. 5, pp. 450–455, 1997. View at: Publisher Site | Google Scholar
  18. A. Shah, A. Ali, S. Latoo, and I. Ahmad, “Multiple Myeloma presenting as Gingival mass,” Journal of Maxillofacial and Oral Surgery, vol. 9, no. 2, pp. 209–212, 2010. View at: Publisher Site | Google Scholar
  19. P. R. Greipp, J. San Miguel, B. G. Durie et al., “International staging system for multiple myeloma,” Journal of Clinical Oncology, vol. 23, no. 15, pp. 3412–3420, 2005. View at: Google Scholar
  20. R. A. Kyle and S. V. Rajkumar, “Multiple myeloma,” Blood, vol. 111, no. 6, pp. 2962–2972, 2008. View at: Publisher Site | Google Scholar
  21. H. Ludwig, K. Strasser-Weippl, M. Schreder, and N. Zojer, “Advances in the treatment of hematological malignancies: current treatment approaches in multiple myeloma,” Annals of Oncology, vol. 18, no. 9, pp. ix64–ix70, 2007. View at: Publisher Site | Google Scholar

Copyright © 2015 Anju E. Thomas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

More related articles

 PDF Download Citation Citation
 Download other formatsMore
 Order printed copiesOrder

Related articles