Dental Considerations in Children with Glucose-6-phosphate Dehydrogenase Deficiency (Favism): A Review of the Literature and Case Report

Table 1

Full-text article finally retrieved and reviewed.

Author(s)	Article type/main findings reported
Chang and Liu [5]	General review/“It is widely accepted that the high frequency of G6PD deficiency has evolved because of the selective pressure exerted by Plasmodium falciparum malaria.”
Mehta et al. [9]	General review/“… there is a risk of neonatal jaundice and acute haemolytic anaemia, triggered by infection and the ingestion of certain drugs and broad beans (favism).”
Quereshy et al. [10]	Dental case report of a 30-year-old African American man/G6PD as a result of a local maxillofacial infection subsequent to a mandibular tooth extraction.
Frank [6]	Diagnosis and management review/the diagnosis of G6PD deficiency is made by a quantitative spectrophotometric analysis or, more commonly, by a rapid fluorescent SPOT test.
Tosun and Sener [7]	Dental case report of a 4-year-old male with Apert syndrome and favism. The patient was in the long term followed up/“… therefore, professional care is necessary and care must be taken for either drug-induced haemolysis or infection, as a result of G6PD deficiency.”
Cappellini and Fiorelli [11]	General review (seminar)/“Fortunately, most G6PD-deficient individuals are asymptomatic throughout their life, and unaware of their status.”
Elyassi and Rowshan [3]	Literature review on the perioperative management of G6PD in anesthesiology/“… management of pain and anxiety should include medications that are safe and have not been shown to cause hemolytic crisis, such as benzodiazepines, Codeine/Codeine derivatives, Propofol, Fentanyl, and Ketamine.”
Youngster et al. [8]	An evidence-based review on medications and G6PD/“… we found solid evidence to prohibit only seven currently used medications: Dapsone, methylthioninium chloride (Methylene Blue), Nitrofurantoin, Phenazopyridine, Primaquine, Rasburicase, and tolonium chloride (Methylene Blue).”
Verdugo et al. [12]	Case report of a Chilean 2-year-and-7-month-old boy/“Among the most common clinical manifestations of this condition, acute hemolysis, chronic hemolysis, neonatal hyperbilirubinemia, and an asymptomatic form are observed.”
Monteiro et al. [4]	Systematic review on prevalence in Latin America/“Low prevalence rates of G6PDd were documented in Argentina, Bolivia, Mexico, Peru, and Uruguay, but studies from Curaçao, Ecuador, Jamaica, Saint Lucia, and Trinidad, as well as some surveys carried out in areas of Brazil, Colombia, and Cuba, have shown a high prevalence (>10%).”