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Case Reports in Dentistry
Volume 2015, Article ID 697673, 6 pages
Case Report

Peripheral Giant Cell Granuloma Associated with a Dental Implant: A Case Report and Review of the Literature

1Department of Pathology, São Leopoldo Mandic Institute and Research Centre, 13045-755 Campinas, SP, Brazil
2Department of Oral Medicine and Oral Surgery, São Leopoldo Mandic Institute and Research Centre, 13045-755 Campinas, SP, Brazil

Received 18 December 2014; Accepted 4 March 2015

Academic Editor: Tommaso Lombardi

Copyright © 2015 Amy Louise Brown et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The peripheral giant cell granuloma (PGCG) is a nonneoplastic lesion commonly caused by local irritation. This report describes a 46-year-old Caucasian male who presented with a PGCG associated with a dental implant. The dental implant was originally placed in August 2012. Ten months later, the patient presented with a well-circumscribed lesion associated with and covering the implant, at which time the lesion was excised. Four months later, due to recurrence of the lesion, a deeper and wider excisional biopsy with curettage of the adjacent bone was performed. No evidence of recurrence has been reported after 12 months of follow-up. Immunohistochemistry, using the antibody CD68, was performed to investigate the origin of the multinucleated giant cells, with their immunophenotype being similar to those of other giant cell lesions, including central giant cell granuloma, foreign-body reactions, and granulomatous reactions to infectious agents.