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Case Reports in Dentistry
Volume 2015 (2015), Article ID 831418, 3 pages
Case Report

Oral Squamous Cell Carcinoma Arising in a Patient after Hematopoietic Stem Cell Transplantation with Bisphosphonate-Related Osteonecrosis of the Jaws

1Department of Surgical Sciences, Oral Medicine Section, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy
2WHO Collaborating Centre for Oral Health-General Health, UK
3University College London, Gower Street, London WC1E 6BT, UK
4Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, Corso Bramante 88, 10126 Turin, Italy

Received 3 February 2015; Accepted 1 April 2015

Academic Editor: Pia Lopez Jornet

Copyright © 2015 Paolo G. Arduino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 55-year-old man with a history of acute myeloid leukaemia treated with hematopoietic stem cell transplantation and with a 5-year history of bisphosphonate-related osteonecrosis of the jaws, following 12 cycles of intravenous zoledronic acid therapy, presented in December 2009 with a history of increasingly severe unilateral lower jaw pain. Oral examination revealed, as previously, exposed bone in the left mandible, but also a new exophytic mass on the lower-left buccal mucosa. Biopsy confirmed a diagnosis of oral squamous cell carcinoma. To the best of our knowledge, this is the first report of an oral squamous cell carcinoma that appeared adjacent to an area of osteochemonecrosis.