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Case Reports in Dentistry
Volume 2016, Article ID 1095927, 6 pages
Case Report

Gingival Enlargement Induced by Felodipine Resolves with a Conventional Periodontal Treatment and Drug Modification

1DB Dental, Corner Tydeman & Pensioner Guard Roads, Perth, WA 6159, Australia
2Irwin Dental Centre, Irwin Barracks, Perth, WA 6010, Australia
3General Dental Practice, School of Dentistry and Oral Health, Griffith University, Gold Coast, QLD 4222, Australia

Received 5 January 2016; Revised 3 February 2016; Accepted 7 February 2016

Academic Editor: Ronald S. Brown

Copyright © 2016 Nabil Khzam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We present a case of a 47-year-old male who suffered from GE around his lower anterior teeth as soon as he started treatment with Felodipine 400 mg. We show that oral hygiene measures, antibiotics, and conventional periodontal treatment (scaling and root planing SRP) were all not sufficient to resolve the drug induced GE, which will persist and/or recur provided that systemic effect of the offending medication is still present. The condition immediately resolved after switching to a different medication. The mechanism of GE is complex and not fully understood yet. It is mainly due to overexpression of a number of growth factors due to high concentrations of calcium ions (Ca2+). This affects fibroblasts proliferation and DNA synthesis and leads to a heavy chronic inflammatory cell infiltrate. Our case was managed according to the suggested protocols in previous case studies. The unique features in our case were the immediate onset of the adverse effect after starting the medication and the absence of any underlying medical condition apart from high blood pressure. Improving the oral hygiene together with SRP and cessation of the medication resolves drug induced GE.