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Case Reports in Dentistry
Volume 2016 (2016), Article ID 1323798, 6 pages
Case Report

The Histopathological Spectrum of Pyogenic Granuloma: A Case Series

1Department of Oral Histology & Pathology, College of Dental Surgery, BP Koirala Institute of Health Sciences, Dharan, Sunsari 56700, Nepal
2Department of Periodontics & Implantology, College of Dental Surgery, BP Koirala Institute of Health Sciences, Dharan, Sunsari 56700, Nepal

Received 10 April 2016; Accepted 19 May 2016

Academic Editor: Pia Lopez Jornet

Copyright © 2016 Vinay Marla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Pyogenic granuloma is a reactive tumor-like lesion commonly affecting the oral cavity. These lesions usually appear as localized solitary nodule with a sessile or pedunculated base and colour varying from red, purplish, or pink, depending on the vascularity of the lesion. Pyogenic granuloma shows predilection for gingiva and is usually slow growing, but at times it shows rapid growth. The natural course of this lesion can be categorized into three distinct phases, namely, (i) cellular phase, (ii) capillary phase/vascular phase, and (iii) involutionary phase. Histopathologically, pyogenic granuloma is classified into lobular capillary hemangioma (LCH) and non-lobular capillary hemangioma (non-LCH). Case Presentation. In this series, four cases (varied age groups and both genders) of pyogenic granuloma showing varying histopathological presentation in relation to its clinical course have been described. The lesion in its early phase reveals diffuse endothelial cells, with few budding into capillaries. Among the capillary phase, the LCH type shows numerous blood vessels organized into lobular aggregates whereas the non-LCH type does not show any such organization and resembles granulation tissue. The involutionary phase shows healing of the lesion and is characterized by extensive fibrosis in the connective tissue. Conclusion. In conclusion, knowledge of the various histopathological presentation of this lesion is necessary for proper identification.