TY - JOUR A2 - Qudeimat, Muawia A. AU - Albuquerque do Nascimento, Leilane Larissa AU - Salgueiro, Monica da Consolação Canuto AU - Quintela, Mariana AU - Teixeira, Victor Perez AU - Mota, Ana Carolina Costa AU - Godoy, Camila Haddad Leal de AU - Bussadori, Sandra Kalil PY - 2016 DA - 2016/07/12 TI - Maxillofacial Changes in Melnick-Needles Syndrome SP - 9685429 VL - 2016 AB - Background. Melnick-Needles Syndrome is rare congenital hereditary skeletal dysplasia caused by mutations in the FLNA gene, which codifies the protein filamin A. This condition leads to serious skeletal abnormalities, including the stomatognathic region. Case Presentation. This paper describes the case of a 13-year-old girl diagnosed with Melnick-Needles Syndrome presenting with different forms of skeletal dysplasia, such as cranial hyperostosis, short upper limbs, bowed long bones, metaphyseal thickening, genu valgum (knock-knee), shortened distal phalanges, narrow pelvis and shoulders, rib tapering and irregularities, elongation of the vertebrae, kyphoscoliosis, micrognathia, hypoplastic coronoid processes of the mandible, left stylohyoid ligament suggesting ossification, and dental development anomalies. Conclusion. Knowledge of this rare syndrome on the part of dentists is important due to the fact that this condition involves severe abnormalities of the stomatognathic system that cause an impact on the development of the entire face as well as functional and esthetic impairments. SN - 2090-6447 UR - https://doi.org/10.1155/2016/9685429 DO - 10.1155/2016/9685429 JF - Case Reports in Dentistry PB - Hindawi Publishing Corporation KW - ER -