Chart of similarities and differences between the reported syndrome and other syndromes with FLNA gene mutation.
Other syndromes caused by mutations in FLNA gene
Similarities between MNS and other syndromes with FLNA gene mutation
Differences between MNS and other syndromes with FLNA gene mutation
Frontometaphyseal dysplasia
(i) Skeletal dysplasia
(i) Supraorbital hyperostosis (ii) Irregular cortex in long bones (iii) Deafness (iv) More severe skeletal and facial manifestations than OPD1 (v) Metacarpophalangeal and interphalangeal joint defects
Otopalatodigital dysplasia type I
(i) Deformities on the tips of fingers and toes (ii) Abnormal palate
(i) Among all, the phenotype is milder in men (ii) Supraorbital hyperostosis (iii) Deafness (iv) Slightly reduced stature
Otopalatodigital dysplasia type II
(i) Abnormal palate
(i) More severe than type I (ii) Facial dimorphism (iii) Hypoplasia of thorax (iv) More accentuated anomalies in fingers and toes (v) Hydrocephalus, obstructive uropathy, heart defects, and omphalocele (vi) Most die in prenatal period or childhood
