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Case Reports in Dentistry
Volume 2018, Article ID 7594840, 8 pages
https://doi.org/10.1155/2018/7594840
Case Report

Multiple, Multiloculated, and Recurrent Keratocysts of the Mandible and Maxilla in Association with Gorlin-Goltz (Nevoid Basal-Cell Carcinoma) Syndrome: A Pediatric Case Report and Follow-up over 5 Years

1Department of Orthodontics, University Medical Center, Göttingen, Germany
2Institute of Human Genetics, University Medical Center, Göttingen, Germany
3Institute of Pathology, University Medical Center, Göttingen, Germany
4Department of Maxillofacial Surgery, University Medical Center, Göttingen, Germany

Correspondence should be addressed to P. Santander; ed.negnitteog-inu.dem@rednatnas.artep

Received 22 May 2018; Revised 12 August 2018; Accepted 9 September 2018; Published 19 September 2018

Academic Editor: Rui Amaral Mendes

Copyright © 2018 P. Santander et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. We report a case of multiple keratocysts first diagnosed in an 8-year-old boy. Case report. The incidental radiographic finding of a cystic lesion in an 8-year-old boy led to the surgical enucleation and further diagnosis of a keratocyst associated with a tooth crown. In the course of dental maturation from deciduous to permanent teeth, the boy presented new lesions, always associated with the crowns of teeth. Gorlin-Goltz (nevoid basal-cell carcinoma) syndrome was suspected, and the genetic analysis detected a previously undescribed germline variant in the PTCH1 gene. Treatment. This included a surgical removal of the cystic lesions, as well as the affected teeth. Follow-up. Due to the high recurrence rate of the keratocysts, frequent radiological checks were performed over a 5-year period.