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Case Reports in Dentistry
Volume 2019, Article ID 1385150, 4 pages
https://doi.org/10.1155/2019/1385150
Case Report

Anxiolysis in the Surgical Management of a Compound Odontoma in a Pediatric Patient

1Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Commenda 10, 20122 Milan, Italy
2Oral Surgery Department, Maxillofacial Surgery and Odontostomatology Unit, Fondazione IRCCS Cà Granda Maggiore Policlinico Hospital, University of Milan, Via Commenda 10, 20122 Milan, Italy
3Oral Surgery and Implantology Departments, Maxillofacial Surgery and Odontostomatology Unit, Fondazione IRCCS Cà Granda Maggiore Policlinico Hospital, University of Milan, Via Commenda 10, 20122 Milan, Italy

Correspondence should be addressed to Silvia Pieriboni; moc.liamg@42inobireip.aivlis

Received 20 September 2018; Accepted 10 March 2019; Published 2 April 2019

Academic Editor: Maria Beatriz Duarte Gavião

Copyright © 2019 Pier Paolo Poli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Among odontogenic tumors, odontoma is the most frequent. The common treatment contemplates a conservative approach. While this procedure is generally accepted and tolerated, some difficulties may be encountered in the case of pediatric patients. Indeed, negative feelings of tension, apprehension, nervousness, and fear are likely to occur. The present report is aimed at discussing the management of a compound odontoma in a pediatric patient under anxiolysis with diazepam on an outpatient basis. The surgery was carried out without complications, and the discharge was completed safely. Oral premedication with diazepam should be considered to avoid more invasive sedation procedures in anxious pediatric patients.

1. Introduction

Odontomas are benign calcifying odontogenic tumors of the oral cavity. Generally, odontomas are considered to be hamartomatous developmental malformations of dental tissues rather than true neoplasms, as both epithelial and ectomesenchymal components have morphologically normal cells with defective structural arrangement [1]. Two basic types of odontoma can be identified: complex and compound. The complex type is characterized by unorganized dental tissue with dysplastic dentin covered by enamel, resulting in haphazard amorphous calcifications. The compound odontoma forms multiple disordered and irregular tooth-like elements [2]. Complex odontomas most frequently occur in the posterior molar regions, whereas compound odontomas tend to develop in the anterior maxilla [3]. The incidence of odontogenic tumors is low, ranging from 0.002% to 0.1%, with the odontoma representing the most common entity, accounting for 20% to 67% of all odontogenic neoplasms [4]. The multifactorial etiology of odontomas is still debated. Local trauma in the primary dentition period, infection growth pressure, hereditary anomalies, family history, and developmental influences have been suggested as possible causes [5]. Most lesions are detected on routine radiographs as a consequence of their slow and painless growth. Eruption disturbances including impaction, delayed eruption, or retention of primary or permanent teeth are common clinical findings [6]. While these lesions can be diagnosed at any age, it is worthy of note that odontomas are considered to be the most common types of odontogenic tumors in the pediatric population [3]. Pediatric dentistry often involves patients with high levels of anxiety and fear. Currently available evidence suggests that approximately 6% [7] to 40% [8] of children exhibit anxiety with respect to dental treatment. Furthermore, anxiety is exacerbated by invasive and long-lasting procedures including surgical interventions [9]. Anxious patients are likely to express subjective feelings of tension, apprehension, nervousness, and fear that might compromise dental treatment. For such reasons, anxiolysis has been used to facilitate dental care for anxious and uncooperative pediatric dental patients with successful results [10]. In view of the above, this report is aimed at presenting a case of compound odontoma surgically managed in association with anxiolysis protocol in a pediatric patient on an outpatient basis.

2. Case Report

A 7-year-old healthy Caucasian boy was referred by the orthodontist to investigate the edentulous space between the first and second primary upper left molars, together with an unusual swelling in the same region. After an interview with the parents, a noncontributory medical history was confirmed.

The intraoral clinical examination revealed mixed dentition with no decayed teeth. A 6 mm edentulous space between the two primary upper left molars was observed. In addition, expansion of the cortical bone was present on the vestibular aspect of the right hemi-maxilla. The bony hard swelling was firm and asymptomatic. The overlying mucosa was normal and nontender on palpation. Second-level radiological investigation was performed by means of the cone-beam computed tomography (CBCT) scan, which confirmed the presence of an irregular radiopaque mass located by the roots of the primary molars (Figure 1).

Figure 1: Cone-beam computed tomography showing radiopaque calcified structures with irregular margins characterized by a tooth-like configuration enclosed in radiolucent peripheral borders. The entire lesion measures approximately mm.

In more detail, the well-corticated lesion was characterized by multiple radiopaque structures encapsulated within a radiolucent cavity. Moreover, the lesion progressed in a vestibular direction so that the permanent second premolar germ resulted dislocated palatally. As a matter of fact, the germ could be palpated on the palatal aspect of the edentulous ridge. The clinical and radiographic presentations led to an initial diagnostic hypothesis of compound odontoma. The suggested treatment plan consisted of surgical removal of the lesion under oral sedation of the patient on an outpatient basis. After discussing the aforesaid surgical procedure, an informed consent signed by the parents was obtained.

Before the surgery, the following vital parameters were recorded: arterial blood pressure (systolic/diastolic pressure ratio: 85/50 mmHg), peripheral capillary oxygen saturation (SpO2: 99%), and heart rate (84 bpm). The weight and height of the patient were also registered (26 kg and 126 cm, respectively). At this point, the anxiolysis protocol used in the department in the case of pediatric patients was adopted (Table 1).

Table 1: Anxiolysis protocol adopted in the case of pediatric patients.

In this specific case, premedication consisted of oral administration of 15 drops of diazepam [11] 3 mg/ml (Valium®, Roche Pharmaceuticals, Monza, Italy) and topical application of 15% lidocaine spray (OGNA Pharmaceuticals, Muggiò, Italy). A fingertip pulse oximeter was used during the entire procedure to monitor the oxygen saturation of the patient.

Local anesthesia was induced with infiltrations of mepivacaine hydrochloride 3% (Optocain® 30 mg/ml, Molteni Dental Srl, Milan, Italy). Crestal incision with vertical releasing incisions located at the mesial and distal aspects of the first and second primary molars, respectively, was performed to raise a trapezoidal mucoperiosteal flap. The odontoma was accessed by removing the thin overlying cortical layer with a round bur mounted on a straight surgical handpiece under copious irrigation of sterile saline (Figure 2).

Figure 2: Intraoral clinical photograph of the surgical access showing the residual bone cavity after removal of the odontoma, with preservation of the adjacent maxillary sinus walls.

The denticles were subsequently exposed and removed in a total of 14 pieces (Figure 3).

Figure 3: Clinical view of the compound odontoma surgically removed in multiple mineralized pieces resembling tooth structures.

All harvested samples were sent for histopathological analysis. The surgical site was debrided and irrigated to remove any remnants, and the integrity of the maxillary sinus walls was checked. First intention sealing of the surgical wound was finally achieved with a 4/0 resorbable suture (Polysorb™, Covidien, Dublin, Ireland).

The time elapsed between the premedication and the end of the surgical procedure was 90 minutes. The vital parameters recorded immediately after the surgery were as follows: arterial blood pressure (systolic/diastolic pressure ratio: 80/50 mmHg), peripheral capillary oxygen saturation (SpO2: 100%), and heart rate (82 bpm).

The patient was prescribed antibiotic therapy consisting of 7.5 ml amoxicillin clavulanate pediatric suspension (Augmentin® pediatric suspension, GlaxoSmithKline, Verona, Italy) 3 times daily for 6 days and analgesics according to the patient needs. The rationale for antibiotic administration was to reduce the risk of infection of the blood clot during the immediate postoperative period in view of the considerable size of the lesion.

Postoperative care instructions included soft warm diet for 48 hours, 0.2% chlorhexidine mouthwash 2 times daily up to suture removal, topical application of ice, and refrainment from mechanical plaque removal of the primary molars for 7 days. The patient was discharged in stable conditions 90 minutes after the end of the surgical procedure. The healing proceeded uneventfully, and sutures were removed after 7 days. The histopathological report provided by the Department of Anatomic Pathology confirmed the diagnosis of compound odontoma (Figure 4).

Figure 4: Low-power magnification of a resected specimen showing dental tissue, dentin, cement, and nonmineralized oral tissue composed of connective tissue typical of dental pulp, partially surrounded by a connective fibrous tissue capsule (hematoxylin and eosin staining; original magnification: ×10).

3. Discussion

The present report described the surgical management of a compound odontoma detected in a pediatric patient with in-office sedation. Heterogeneity can be found among data reported from the literature with respect to the epidemiology of the disease. The present case is consistent with other studies reporting that compound odontoma is more frequently diagnosed in male subjects [6, 12] during the first two decades of life [13] in the premaxillary region [14]. Also, the clinical and radiological characteristics of the odontoma diagnosed in the present case resemble those commonly encountered for this type of lesion. Clinically, a firm bony swelling of the oral vestibule covered by normal mucosa with no signs of inflammation can be appreciated [15]. Although they are commonly asymptomatic, clinical manifestations may occur, such as retention of deciduous teeth, noneruption of permanent teeth, and tooth displacement [13]. These clinical findings, if recognized, might explain the early diagnosis achieved in the present report. Dentition anomalies, and in particular the retention of the permanent second premolar, have led to a radiological second-level investigation which confirmed the suspect of compound odontoma. As a matter of fact, the CBCT exams showed multiple radiopaque tooth-like structures of various sizes surrounded by a radio-lucid halo, compatible with compound odontoma at an advanced stage of development [13]. It is noteworthy that the mean age of patients at diagnosis of odontoma is normally between 20 and 30 years [4, 16, 17], with a mean age reported for compound odontoma of 20.5 years [17]. Conservative surgical enucleation and curettage were performed as the treatment of choice [3]. As mentioned above, extended dental treatments such as oral surgery procedures may cause deterioration of the pediatric patient behavior associated with dental fear and dental anxiety [9]. In particular, dental anxiety indicates an excessive and unreasonable negative emotional state that might jeopardize the outcome of the procedure [18]. In such cases, anxiolysis, better known as minimal sedation, might be advocated to induce a state of a minimally depressed level of consciousness with ventilatory and cardiovascular functions unaffected [19]. In the present report, this effect has been positively exploited to minimize the psychological trauma and to control behavior and movements of the pediatric patient. Among benzodiazepines, diazepam has been used for many years successfully. It has been claimed that diazepam represents the safer drug for anxiety management in dentistry if compared to midazolam due to its pharmacological profile [20]. Other authors observed no differences between the behaviors of children premedicated with oral diazepam or oral midazolam [21]. Conversely, emerging evidence provided better results for oral midazolam with respect to oral diazepam when the behavioral parameters including sleep, crying, movement, and overall behavior were compared [22]. In the present case, the immediate postoperative period was uneventful, and the patient was discharged safely 90 minutes postsurgery. It must be noted however that postdischarge excessive somnolence, nausea, and emesis have been frequently reported after oral sedation in pediatric dental patients [23]. Anxiolysis with oral administration of diazepam induced positive psychological responses to treatment and safe discharge. This procedure should therefore be considered in the case of potentially prolonged surgical interventions in pediatric dental patients to avoid more invasive sedation procedures.

Conflicts of Interest

All authors declare no conflict of interest.

References

  1. P. Gonzalez-Alva, H. Inoue, Y. Miyazaki et al., “Podoplanin expression in odontomas: clinicopathological study and immunohistochemical analysis of 86 cases,” Journal of Oral Science, vol. 53, no. 1, pp. 67–75, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. F. Prætorius and A. Piattelli, “Odontogenic tumours,” WHO Classification of Tumours Pathology and Genetics of Head and Neck Tumours, L. Barnes, J. W. Evenson, P. A. Reichart, and D. Sindransky, Eds., IARC Press, Lyon, France, 2005. View at Google Scholar
  3. J. M. Abrahams and S. A. McClure, “Pediatric odontogenic tumors,” Oral and Maxillofacial Surgery Clinics of North America, vol. 28, no. 1, pp. 45–58, 2016. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Boffano, E. Zavattero, F. Roccia, and C. Gallesio, “Complex and compound odontomas,” Journal of Craniofacial Surgery, vol. 23, no. 3, pp. 685–688, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Gervasoni, A. Tronchet, S. Spotti et al., “Odontomas: review of the literature and case reports,” Journal of biological regulators and homeostatic agents, vol. 31, Supplement 1, no. 2, pp. 119–125, 2017. View at Google Scholar
  6. G. Isola, M. Cicciù, L. Fiorillo, and G. Matarese, “Association between odontoma and impacted teeth,” Journal of Craniofacial Surgery, vol. 28, no. 3, pp. 755–758, 2017. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Olak, M. Saag, S. Honkala et al., “Children’s dental fear in relation to dental health and parental dental fear,” Stomatologica, vol. 15, pp. 26–31, 2013. View at Google Scholar
  8. V. Colares, C. Franca, A. Ferreira, H. A. Amorim Filho, and M. C. A. Oliveira, “Dental anxiety and dental pain in 5- to 12-year-old children in Recife, Brazil,” European Archives of Paediatric Dentistry, vol. 14, no. 1, pp. 15–19, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. Z. Jamali, E. Najafpour, Z. Ebrahim Adhami, A. Sighari Deljavan, N. A. Aminabadi, and S. Shirazi, “Does the length of dental procedure influence children’s behavior during and after treatment? A systematic review and critical appraisal,” Journal of Dental Research, Dental Clinics, Dental Prospects, vol. 12, no. 1, pp. 68–76, 2018. View at Publisher · View at Google Scholar
  10. R. K. Pandey, S. K. Bahetwar, A. K. Saksena, and G. Chandra, “A comparative evaluation of drops versus atomized administration of intranasal ketamine for the procedural sedation of young uncooperative pediatric dental patients: a prospective crossover trial,” Journal of Clinical Pediatric Dentistry, vol. 36, no. 1, pp. 79–84, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Manani, C. Bacci, G. Zanette, and E. Facci, “Compound Odontoma in Anterior Mandible—A Case Report,” Dental Cadmos, vol. 80, no. 7, pp. 357–369, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Uma, “Compound odontoma in anterior mandible-a case report,” Malaysian Journal of Medical Sciences, vol. 24, no. 3, pp. 92–95, 2017. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Gedik and S. Muftuoglu, “Compound odontoma: differential diagnosis and review of the literature,” West Indian Medical Journal, vol. 63, no. 7, pp. 793–795, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. B. H. De Oliveira, V. Campos, and S. Marcal, “Compound odontoma--diagnosis and treatment: three case reports,” Pediatric Dentistry, vol. 23, no. 2, pp. 151–157, 2001. View at Google Scholar
  15. A. Kalra, E. C. Sheehy, J. Johnson, and F. McDonald, “A bag of marbles: a fascinating compound odontoma of the maxilla,” Pediatric dentistry, vol. 40, pp. 140–142, 2018. View at Google Scholar
  16. C. Bereket, N. Cakir-Ozkan, I. Sener et al., “Complex and compound odontomas: analysis of 69 cases and a rare case of erupted compound odontoma,” Nigerian Journal of Clinical Practice, vol. 18, no. 6, pp. 726–730, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. P. W. Kammerer, D. Schneider, E. Schiegnitz et al., “Clinical parameter of odontoma with special emphasis on treatment of impacted teeth—a retrospective multicentre study and literature review,” Clinical Oral Investigations, vol. 20, no. 7, pp. 1827–1835, 2016. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Klingberg and A. G. Broberg, “Dental fear/anxiety and dental behaviour management problems in children and adolescents: a review of prevalence and concomitant psychological factors,” International Journal of Paediatric Dentistry, vol. 17, no. 6, pp. 391–406, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. “Practice guidelines for moderate procedural sedation and analgesia 2018: a report by the American Society of Anesthesiologists Task Force on Moderate Procedural Sedation and Analgesia, American Association of Oral and Maxillofacial Surgeons, American College of Radiology, American Dental Association, American Society of Dentist Anesthesiologists, and Society of Interventional Radiology,” Anesthesiology, vol. 128, no. 3, pp. 437–479, 2018. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Manani, E. Facco, L. Favero et al., “Comparison by means of bispectral index score, between anxiolysis induced by diazepam and sedation induced by midazolam,” Minerva Stomatologica, vol. 60, no. 7-8, pp. 365–381, 2011. View at Google Scholar
  21. T. R. Vetter, “A comparison of midazolam, diazepam, and placebo as oral anesthetic premedicants in younger children,” Journal of Clinical Anesthesia, vol. 5, no. 1, pp. 58–61, 1993. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Tyagi, S. Tyagi, and A. Jain, “Sedative effects of oral midazolam, intravenous midazolam and oral diazepam in the dental treatment of children,” Journal of Clinical Pediatric Dentistry, vol. 37, no. 3, pp. 301–306, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Huang and T. Tanbonliong, “Oral sedation postdischarge adverse events in pediatric dental patients,” Anesthesia Progress, vol. 62, no. 3, pp. 91–99, 2015. View at Publisher · View at Google Scholar · View at Scopus