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Case Reports in Dermatological Medicine
Volume 2013, Article ID 473635, 6 pages
Case Report

Giant Congenital Melanocytic Naevus with Proliferative Nodules Mimicking Congenital Malignant Melanoma: A Case Report and Review of the Literature of Congenital Melanoma

1Department of Dermatology, Federico II University, via Pansini 5, 80131 Naples, Italy
2Department of Neonatal Intensive Care, Federico II University, via Pansini 5, 80131 Naples, Italy
3Department of Biomorphological and Functional Science, Federico II University, via Pansini 5, 80131 Naples, Italy
4Institute of Pathology, University of Basel, 4003 Basel, Switzerland

Received 26 November 2012; Accepted 24 December 2012

Academic Editors: S. A. Cuevas-Covarrubias, M. J. Fellner, S. Inui, K. Jimbow, and K. E. Sharquie

Copyright © 2013 Massimiliano Scalvenzi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Congenital malignant melanoma (CMM) is a rare condition that is defined as malignant melanoma recognized at birth. CMM may develop in utero in one of three ways: (1) transmission by metastasis through the placenta from a mother with melanoma; (2) primary melanoma arising within a giant congenital melanocytic naevus (GCMN); (3) primary de novo cutaneous CMM arising in utero. CMM can be confused clinically and histologically with benign proliferative melanocytic lesions such as giant congenital nevi. We describe the case of a patient presenting a GCMN with proliferative nodules, clinically and dermoscopically resembling a CMM, demonstrating the importance of caution in making a diagnosis of MM and highlighting the possibility that benign lesions as GCMN can mimic a malignant melanoma in this age group.