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Case Reports in Dermatological Medicine
Volume 2015 (2015), Article ID 320620, 2 pages
http://dx.doi.org/10.1155/2015/320620
Case Report

A Case of Recalcitrant Plantar Warts Associated with Statin Use

Department of Dermatology, Sandwell and West Birmingham NHS Trust, Birmingham B18 7QH, UK

Received 18 January 2015; Accepted 12 February 2015

Academic Editor: Xing-Hua Gao

Copyright © 2015 Aaron G. Wernham and Shireen S. Velangi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Plantar warts are a common presenting skin complaint caused by the human papillomavirus. 1st line therapies include cryotherapy and topical salicylic acid. Where there is resistance to these treatments, consideration is made for 2nd line therapies, including intralesional bleomycin, imiquimod, 5-fluorouracil, and photodynamic therapy. We present a case of bilateral persistent plantar warts, resistant to treatment with repeated cryotherapy and topical salicylic acid over a 6-year period. Following a patient initiated decision to discontinue their statin medication, we observed rapid clearance of plantar warts without change to standard therapy or their environment. This case correlates with emerging literature demonstrating a link between statin medication and proliferation of HPV through increased levels of FOXP3+ regulatory T cells.