Methotrexate Treatment in Children with Febrile Ulceronecrotic Mucha-Habermann Disease: Case Report and Literature Review

Figure 1

(a) Erythematous macules, papules, and pustules on the trunk. (b) Histopathology of the skin lesion showing parakeratosis, extension of infiltrate into epidermis, vacuolization of basal layer with necrotic keratinocytes, and mixed inflammatory cell infiltration around the vessels and in the upper dermis (HE ×200). (c) Necrotic ulcers, erythematous papules, and plaques on the limbs. (d) Clinical appearance after six doses of methotrexate. (e) Clinical appearance five months after the patient’s initial visit.

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