Case Reports in Dermatological Medicine / 2021 / Article / Tab 1

Case Series

A Multimodal Hair-Loss Treatment Strategy Using a New Topical Phytoactive Formulation: A Report of Five Cases

Table 1

Components of Dr. UGro Gashee®.

Generic nameINCI nameProperties

Gotu kolaCentella asiaticaActivates hair-inductive capacity in three-dimensional spheroid cultured dermal papilla cells [33]
Aloe barbadensis extractAloe barbadensis extractImmunomodulatory and anti-inflammatory properties [34]
Red (Asian) ginseng extractPanax root ginseng extractMay reduce hair loss despite the presence of DKK-1, a strong catagen inducer via apoptosis [35]
Polygonum fo-ti extractPolygonum multiflorum root extractIncreases the proliferation of dermal papillary cells [36]
Cysteine/N-acetyl-cysteineCysteine/N-acetyl cysteineAndrogen-inducible TGF-β1 promotes androgenetic alopecia; however, it is significantly suppressed by the ROS scavenger, N-acetyl cysteine [37]
TurmericCurcuma longaScavenger of reactive oxygen species, anti-inflammatory agent, and immunomodulator [38, 39]; anti-androgen [40] inhibits androgenic induction of TGF-β, which induces catagen and inhibits hair growth and perifollicular fibrosis [4143]
Horsetail extractEquisetum arvense extract5α-reductase inhibitor [44]
Fenugreek oilTrigonella foenum-graecum oilAnti-inflammatory, antioxidant, antifungal, and antibacterial properties [45]
Tall oil fatty acidsTall oil fatty acidβ-Sitosterol component may be an effective 5-alpha reductase inhibitor [46]
Green tea extract with 95% EGCGCamellia sinensis leaf extractPhytoconstituent epigallocatechin 3-gallate is a 5-α reductase inhibitor [47]
Saw palmettoSerenoa serrulataInhibits both isoforms of 5-α reductase, preventing conversion of testosterone to its active form, DHT, and also promotes hair follicle vascularization [48, 49]
Eclipta alba oilEclipta alba (bhringraj oil)Stimulates follicular keratinocyte proliferation and delays terminal differentiation by downregulating TGF-β1 expression [50]
Vitamin D3Vitamin D3Animal studies show that vitamin D3 analogs stimulate hair regrowth [51]

DHT: 5-dihydrotestosterone; DKK-1: Dickkopf WNT signaling pathway inhibitor 1; EGCG: epigallocatechin gallate; IGF-1: insulin growth factor 1; INCI: International Nomenclature of Cosmetic Ingredients; ROS: reactive oxygen species; TGF: transforming growth factor.