Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Endocrinology
Volume 2011, Article ID 246872, 3 pages
Case Report

Endometrioid Adenocarcinoma Metastatic to the Thyroid, Presenting Like Anaplastic Thyroid Cancer

1Department of Otolaryngology-Head and Neck Surgery, Temple University School of Medicine, Kresge West, 3rd floor, 3400 North Broad Street, Philadelphia, PA 19140, USA
2Department of Otolaryngology-Head and Neck Surgery, University of Missouri-Columbia, Columbia, MO 65212, USA
3Department of Pathology and Laboratory Medicine, Albert Einstein Medical Center, Philadelphia, PA 19141, USA
4Department of Pathology and Anatomical Sciences, University of Missouri-Columbia, Columbia, MO 65212, USA

Received 17 May 2011; Accepted 21 June 2011

Academic Editors: G. Aimaretti, A. Memon, and S. Vasikaran

Copyright © 2011 Natasha Pollak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Metastasis of uterine cancer to the head and neck is extremely rare. We report what we believe to be the first documented case of endometrioid adenocarcinoma metastasizing to the thyroid gland. An 80-year-old woman was referred to the otolaryngology service with a rapidly growing neck mass. The mass appeared to originate from the thyroid gland. Her clinical presentation was consistent with anaplastic thyroid carcinoma. A tracheostomy was performed. An open biopsy established the diagnosis of moderately differentiated adenocarcinoma, consistent with a gynecologic primary. The patient had undergone a hysterectomy 5 years prior for endometrioid adenocarcinoma. The thyroid tumor histology and immunophenotype corresponded well with her prior endometrial carcinoma, indicating that the thyroid mass was a metastasis from the endometrial primary. Radiotherapy appears to offer good local disease control in this rare case of endometrioid adenocarcinoma metastatic to the thyroid.