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Case Reports in Endocrinology
Volume 2012, Article ID 168671, 3 pages
Case Report

Insulinoma Causing Liver Metastases 15 Years after Initial Surgery, Accompanied by Glomerulonephritis

Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center Ljubljana, Zaloska 7, 1000 Ljubljana, Slovenia

Received 25 September 2012; Accepted 4 November 2012

Academic Editors: I. Broom, O. Isozaki, and M. K. Shakir

Copyright © 2012 A. Janez. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Insulinoma is a rare pancreatic endocrine tumor that is typically sporadic, solitary, and less than 2 cm in diameter. Ninety percent of all insulinomas are benign. Up to 10 percent are malignant and are usually larger in size. We report a case of an unusual, not yet described association of two diseases: a malignant pancreatic insulinoma recurred as a multiple liver metastasis 15 years after the initial complete enucleation of a primary tumor with a histomorphological fairly benign outlook, accompanied by ANCA positive crescentic glomerulonephritis.