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Case Reports in Endocrinology
Volume 2012, Article ID 468609, 4 pages
Case Report

Improved Diabetes Control and Pancreatic Function in a Type 2 Diabetic after Omeprazole Administration

Fort Bend Premier Care, 1505 Liberty Street, Richmond, TX 77469, USA

Received 24 December 2011; Accepted 9 January 2012

Academic Editors: K. Iida, H. Ikeda, M. P. Kane, and R. Swaminathan

Copyright © 2012 I. N. Mefford et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 43-year-old man with type 2 diabetes, opposed to insulin use and poorly responsive to oral agents added sequentially over 6 years, was placed on 40 mg omeprazole twice daily. A linear decline in daily fasting blood glucose was observed over the first two-month treatment, and his hemoglobin A1c was reduced from 11.9% to 8.2%, then sustained at 8.1% after four months. Glucose, insulin, and C-peptide response to a 2-hour glucose tolerance test were consistently improved across this time period, and calculated beta-cell mass increased by 67%. We believe these responses are consistent with activation or neogenesis of pancreatic beta cells, possibly through a gastrin-mediated mechanism.