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Case Reports in Endocrinology
Volume 2013 (2013), Article ID 356086, 4 pages
http://dx.doi.org/10.1155/2013/356086
Case Report

Pure Androgen-Secreting Adrenal Adenoma Associated with Resistant Hypertension

Endocrinology Division, University Hospital “Dr. José E. González,” Universidad Autonoma de Nuevo León, 64460 Monterrey, NL, Mexico

Received 19 April 2013; Accepted 15 May 2013

Academic Editors: C. Capella and B. K. Irons

Copyright © 2013 René Rodríguez-Gutiérrez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pure androgen-secreting adrenal adenoma is very rare, and its diagnosis remains a clinical challenge. Its association with resistant hypertension is uncommon and not well understood. We present an 18-year-old female with a 10-year history of hirsutism that was accidentally diagnosed with an adrenal mass during the evaluation of a hypertensive crisis. She had a long-standing history of hirsutism, clitorimegaly, deepening of the voice, and primary amenorrhea. She was phenotypically and socially a male. FSH, LH, prolactin, estradiol, 17-hydroxyprogesterone, and progesterone were normal. Total testosterone and DHEA-S were elevated. Cushing syndrome, primary aldosteronism, pheochromocytoma, and nonclassic congenital adrenal hyperplasia were ruled out. She underwent adrenalectomy and pathology reported an adenoma. At 2-month followup, hirsutism and virilizing symptoms clearly improved and blood pressure normalized without antihypertensive medications, current literature of this unusual illness and it association with hypertension is presented and discussed.