Case Reports in Endocrinology

Case Reports in Endocrinology / 2013 / Article

Case Report | Open Access

Volume 2013 |Article ID 379852 |

Subramanian Kannan, Ankita Satra, Amir Hamrahian, "Incidental Lipid Poor Adrenal Mass in a Patient with Antiphospholipid Syndrome", Case Reports in Endocrinology, vol. 2013, Article ID 379852, 3 pages, 2013.

Incidental Lipid Poor Adrenal Mass in a Patient with Antiphospholipid Syndrome

Academic Editor: C. Capella
Received30 Nov 2012
Accepted18 Jan 2013
Published20 Feb 2013


Adrenal incidentalomas are commonly encountered in this era of ubiquitous imaging. The attenuation of the incidentaloma measured in Hounsfield units (HU) is an important step in the work up. Attenuation less than 10 HU indicates a benign lesion in more than 98% of cases, whereas attenuation greater than 30 HU is highly suspicious for adrenocortical cancer (ACC). Adrenal hematoma is rarely suspected clinically and exhibits no specific clinical symptoms or laboratory findings. There are multiple radiological features of adrenal hemorrhage and can mimic ACC. We present a case of an adrenal mass in a patient with antiphospholipid syndrome and discuss radiological clues to differentiate adrenal hematomas from ACC and thus avoid unnecessary surgical intervention.

1. Case Report

A 65-year-old male with past history of anti-phospholipid (APL) syndrome on coumadin was admitted for acute right sided pleuritic chest pain. He was recently bridged with low molecular weight heparin after a right knee replacement. The CT-angiogram of the chest revealed a pulmonary infarct and a 5 cm right adrenal mass. A dedicated CT of his adrenals confirmed a right adrenal mass of  cm with pre-contrast attenuation of 53 Hounsfield units (HU) (Figure 1) with evidence of fat stranding, a sign of blood infiltrating fat containing retroperitoneal soft tissue, surrounding it. The left adrenal gland was thickened. A review of the patient’s imaging studies was notable for normal adrenal glands on a CT scan two years ago. Lab work-up revealed a cortisol level of 4.4 mcg/dL after 1 mg dexamethasone suppression test, a normal plasma ACTH 28 pg/mL (8–42), and a slightly elevated plasma normetanephrine 1.2 nmol/L (<0.9). Given the clinical circumstances of APL syndrome, history of anticoagulation and radiological features, a close monitoring of the adrenal mass was planned. A repeat CT scan at 2 months showed a decrease in right adrenal mass and noncontrast CT attenuation value to  cm and 32 HU, respectively. Another CT scan done at 4 months showed 50% reduction in size (  cm) and attenuation reduced to 21 HU (Figure 2(a)). The CT washout showed no significant enhancement or de-enhancement (Figure 2(b)). Left adrenal gland appeared normal. What is the diagnosis?

2. Discussion

The various causes of an incidentally detected adrenal mass are listed in Table 1. Patient’s adrenal mass imaging characteristics are consistent with an adrenal hematoma. The 1 mg dexamethasone suppression test was repeated on outpatient basis and subclinical cushing’s syndrome was ruled out.

(a) Adrenal cortical tumors
 Adenoma, nodular hyperplasia, and congenital adrenal hyperplasia
(b) Adrenal medullary tumors
(c) Other adrenal tumors
 Miscellaneous, for example, hamartoma, teratoma, lipoma,
  Fungal: (histoplasmosis, coccidiomycosis, blastomycosis)
  Viral: CMV
 Cysts and pseudocysts

Adrenal hematomas may present as a solid mass with high attenuation value (50–90 HU) on CT scan. In contrast to adrenal metastasis and adrenocortical carcinoma they do not enhance with contrast and therefore have a very low washout percentage [1]. Adrenal hematomas decrease in size and attenuation on follow-up imaging and the majority undergo complete resolution [2]. The appearance of an adrenal hematoma on MRI evolves predictably over time due to the different components of acute, subacute, and chronic hemorrhage (deoxyhemoglobin, methemoglobin, and hemosiderin).

Acute adrenal hematomas appear isointense to hypointense relative to liver on T1-weighted images and hypointense on T2-weighted images due to deoxyhemoglobin. Subacute hematomas appear heterogeneous and hyperintense on T1- and T2-weighted images due to methemoglobin, while chronic hematomas exhibit peripheral hypointensity due to the susceptibility effects from the accumulation of hemosiderin and development of a fibrous capsule [4]. Other patterns of adrenal hematoma include infiltrative pattern where there is soft tissue stranding in the retroperitoneum, adreniform pattern with enlargement of the limbs of adrenal gland, and a solid mass with cystic center. The latter may also suggest the presence of hemorrhage in an underlying mass and prompts surgical excision for conclusive diagnosis [2]. Bilateral adrenal hemorrhages may present with primary adrenal insufficiency [5]. Consideration of adrenal hematoma in the differential diagnosis of a lipid poor adrenal mass is very important since unnecessary surgical intervention can be avoided.

Follow-up imaging in 2-3 months is necessary to confirm the diagnosis and rules out malignant adrenal masses.


  1. N. R. Dunnick and M. Korobkin, “Imaging of adrenal incidentalomas: current status,” American Journal of Roentgenology, vol. 179, no. 3, pp. 559–568, 2002. View at: Google Scholar
  2. M. G. Sacerdote, P. T. Johnson, and E. K. Fishman, “CT of the adrenal gland: the many faces of adrenal hemorrhage,” Emergency Radiology, vol. 19, no. 1, pp. 53–60, 2012. View at: Publisher Site | Google Scholar
  3. D. C. Aron, “Incidentalomas. Preface,” Best Practice and Research: Clinical Endocrinology and Metabolism, vol. 26, no. 1, pp. 1–2, 2012. View at: Google Scholar
  4. J. I. Rubin, J. M. Gomori, and R. I. Grossman, “High-field MR imaging of extracranial hematomas,” American Journal of Roentgenology, vol. 148, no. 4, pp. 813–817, 1987. View at: Google Scholar
  5. M. A. Satta, S. M. Corsello, S. Della Casa et al., “Adrenal insufficiency as the first clinical manifestation of the primary antiphospholipid antibody syndrome,” Clinical Endocrinology, vol. 52, no. 1, pp. 123–126, 2000. View at: Publisher Site | Google Scholar

Copyright © 2013 Subramanian Kannan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Related articles

No related content is available yet for this article.
 PDF Download Citation Citation
 Download other formatsMore
 Order printed copiesOrder

Related articles

No related content is available yet for this article.

Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.