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Case Reports in Endocrinology
Volume 2014, Article ID 194716, 4 pages
Case Report

Testicular “Hyperstimulation” Syndrome: A Case of Functional Gonadotropinoma

1Topiwala National Medical College and BYL Nair Charitable Hospital, Mumbai 400008, India
2Endocrinology, Diabetes & Metabolism Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
3Institute of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
4Brain Tumor & Neuro-Oncology Center, Department of Neurosurgery, The Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA

Received 17 November 2013; Accepted 22 December 2013; Published 28 January 2014

Academic Editors: M. Demura, L. Mastrandrea, and T. Nagase

Copyright © 2014 Astha Thakkar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Gonadotropins secreting pituitary tumors tend to present as sellar mass with hypogonadism. Biologically active LH secretion by these tumors resulting in elevated testosterone is extremely rare. We report a case of a 48-year-old male patient who presented with giant pituitary tumor, elevated testosterone, and elevated levels of gonadotropins. Surgical resection of the tumor resulted in normalization of gonadotropins and fall in serum testosterone to subnormal levels in the postoperative period confirming that the tumor was secreting bioactive luteinizing hormone (LH).