|
| Authors | Year | Cell type* | Pituitary complications | Known thyroid primary | Timing from thyroid primary | RAI if known thyroid primary | Other Rx | Other sites of metastases | Age | Sex | Rx | Outcomes |
|
|
Johnson and Atkins [8] |
1965 | P | Visual field defect
CN III, CN IV | Yes | 14 years | No | External beam RT | Local recurrence | 56 | F | Roentgen therapy
Adjuvant RAI | Follow-up |
|
| Pelosi et al. [10] | 1977 | P | Hypopituitarism
Ophthalmoplegia | No | NA | NA | No | No | 32 | M | Transcranial surgery | Death 1 month after presentation |
|
| Sziklas et al. [11] | 1985 | P | Hypopituitarism
DI | Yes | 25 years | No | No | Bone
Chest wall | 44 | M | Transsphenoidal resection
RAI | Death 13 months after due to massive intrathoracic haemorrhage |
|
Masiukiewicz et al.
(Case 1) [12] | 1999 | P | Central hypothyroidism Hypogonadism
Hypoadrenalism | Yes | 5 years | Yes, at diagnosis and repeated doses for recurrence | Repeated surgical clearance | Repeated local recurrence
Lungs | 56 | M | No surgery
RAI | Progressive lung and bone metastases |
|
| Masiukiewicz et al. (Case 2) [12] | 1999 | P | CN III deficit
Hypogonadism | Yes | 20 years | Yes, several years after diagnosis without clinical response | Radiosurgery | Local recurrence Bone
Lungs | 55 | F | Stereotactic radiosurgery
Surgical debulking
RAI | Death after 7 months |
|
| Bell et al. [13] | 2001 | P | Visual field defect
DI
Amenorrhea | Yes | 25 years | For pulmonary metastases 8 years after thyroidectomy | Neck RT at diagnosis of thyroid cancer | Lung | 35 | F | Transsphenoidal resection | Follow-up
DI post-op |
|
| Barbaro et al. (Case 2) [14] | 2013 (2011) | P | Ophthalmoplegia | Yes | 2 months | Yes | No | No | 65 | F | Surgical intervention
EBRT | Follow-up for 2 months |
|
| Trunnell and Marinelli [15] | 1949 | F | Visual field defect | Yes | 1 year | No | No | Bone | 42 | F | 2 RAI | Follow-up |
|
|
Kistler and Pribram [16] | 1975 | F | Visual field defect
CN III | Yes | 9 years | Yes | No | No | 69 | F | Craniotomy but unresectable
Autopsy confirming thyroid metastases | Death |
|
| Ochiai et al. [17] | 1992 | F | CN III, CN IV | No | NA | NA | NA | No | 62 | F | Transsphenoidal resection
RAI | Follow-up
Hormonal replacement therapy |
|
| Chrisoulidou et al. [18] | 2004 (case 1996) | F | CN III | Yes | 4 years | Yes | External beam RT
Chemo (paraplatin/vepeside) | No | 60 | M | Transsphenoidal resection | Follow-up
Hormonal suppressive therapy
Hormonal replacement |
|
| Simon et al. [19] | 2004 | F | CN III, CN IV
Raised ICP | No | NA | NA | NA | No | 23 | F | Transsphenoidal surgery abandoned RAI | Follow-up |
|
| Yilmazlar et al. [20] | 2004 | F | Visual field defect
Raised ICP
Galactorrhea | Yes | 22 months | Yes | No | No | 43 | F | Transsphenoidal resection
RAI × 3
Hormonal suppressive therapy | Follow-up |
|
| Prodam et al. [4] | 2010 | F | Visual disturbance
Raised ICP
Stalk effect
Transient DI post-op | No | NA | RAI after thyroidectomy after pituitary lesion was found | No | Local lymph nodes
Pelvic mets | 45 | F | Transsphenoidal surgery
RAI | Follow-up
KIV for 3rd RAI |
|
| Vianello et al. [21] | 2011 (case 2001) | F | Visual field deficits
Pain to right orbit
Hypopituitarism | No | NA | RAI after thyroidectomy after pituitary lesion was found | External beam RT | Lung
Bone
Soft tissue, muscle
Skull | 61 | F | Transnasopharyngeal biopsy
Total thyroidectomy
External beam radiotherapy to sellar
RAI × 7 | Follow-up for 10 years |
|
| Bhatoe et al. [22] | 2008 (case 2001) | M | Visual field defect
Stalk effect
Hypogonadism-decreased libido, gynecomastia | No | NA | NA | NA | No | 36 | M | Craniotomy and subfrontal resection
Adjuvant radiotherapy | Follow-up for 9 months |
|
| Santarpia et al. [23] | 2009 (2005) | M | Raised intracranial pressure
Visual field deficit
DI
Panhypopituitarism | Yes | 15 years | No | No | Local lymph nodes
Bone
Lungs
Liver | 23 | F | Transsphenoidal resection | Death 2 months after surgery due to intercurrent infection |
|
| Williams et al. [24] | 2008 | M | DI
Visual field deficit | Yes | 15 years | No | No | Lung
Bone
Liver
Breast | 23 | F | Transsphenoidal resection | Follow-up |
|
| Bobinski et al. [25] | 2009 | M | Apoplexy
Hydrocephalus
Large suprasellar mass | No | NA | NA | NA | No | 46 | F | Craniotomy and tumour debulking | Death |
|
| Conway et al. [26] | 2012 | M | DI
Panhypopituitarism | No | NA | NA | NA | Parotid
Bilateral adrenals
Bone
Cerebellum | 61 | M | Craniotomy
Palliative radiation to pituitary and combination chemotherapy | Follow-up for 13 months |
|
| Case 1 | 2011 | A | CN III | Yes | 26 days | Yes | RT | Lymph node
Bone | 50 | F | RT
RAI | Death |
|
| Case 2 | 2010 | F | Panhypopituitarism
DI
Optic neuropathy | No | NA | Yes | NA | Bone
Lungs | 65 | F | Transsphenoidal surgery
RAI | Death |
|
