Calcitonin-Secreting Neuroendocrine Carcinoma of Larynx with Metastasis to Thyroid

Table 2

Features favoring diagnosis of MDNC of larynx.

Features favoring diagnosis of MDNC of larynx	Features disfavoring MDNC of larynx
Age & sex	Bilateral C-cell hyperplasia of thyroid
Smoking history
Clinical presentation of neck mass, hoarseness, and odynophagia
Supraglottic location of primary tumor
Normal serum CEA
Serum calcitonin level compared to tumor volume
Bilateral lateral cervical lymph node involvement
Extensive lymph-vascular space invasion by tumor in lymph nodes
Only focally positive TTF-1 staining in primary tumor and thyroid tumor
Subcutaneous nodule metastases without overlying skin changes
Negative amyloid stains of thyroid tumor and lymph node metastasis

RET mutation testing pending.