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Case Reports in Endocrinology
Volume 2015 (2015), Article ID 670809, 7 pages
Case Report

Characteristics and Treatment Results of 5 Patients with Fibrous Dysplasia and Review of the Literature

1Endocrinology Department, Ege University Faculty of Medicine, Izmir, Turkey
2Endocrinology Department, Recep Tayyip Erdogan University Faculty of Medicine, Rize, Turkey

Received 10 January 2015; Accepted 1 June 2015

Academic Editor: Suat Simsek

Copyright © 2015 Nilufer Ozdemir Kutbay et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. Fibrous dysplasia is a rare bone disease caused by missense mutation leading to abnormal fibroblast and osteoblast proliferation and increased bone resorption. FD can present in monostotic or polyostotic forms. About 3% of FD could be in association with McCune-Albright syndrome (MAS). Because FD is a rare disease, there is limited data in the literature about characteristics of disease and response to treatment. Methods. We present our five cases of FD with general properties and their responses to medical treatment. Results. Two of our patients had polyostotic and three had monostotic FD. One of the polyostotic patients had MAS. One of our patients had surgery for femur fractures, facial asymmetry, and findings of compression. Four patients were given pamidronate; one was given zoledronic acid as bisphosphonate treatment. Bone pain was relieved in all patients with medical treatment. Conclusion. There was a decrease in bone turnover markers to some degree with medical treatment but no radiological improvement was observed.