Mifepristone Accelerates HPA Axis Recovery in Secondary Adrenal Insufficiency

Table 1

Time course of HPA axis recovery after initiation of mifepristone.

Month	0	1	3	4	5	6	8	10	11
Mife. dose (mg)	0	150 TIW	300 TIW	300 daily	600 daily	600 daily	300 TIW	0	0
HC dose (mg)	15	15	15	15	15	10	0	0	0
ACTH (pg/mL)	5	15	18	60	78	173	126	26	45
Cortisol (g/dL)	<1	<1	<1	3.6	4.6	10.5	13.6	13.5	15.3
DHEA (ng/mL)	<0.05	<0.05	<0.05	<0.05	<0.05	<0.05	<0.05	<0.05	0.053

Mife.: mifepristone; HC: hydrocortisone; ACTH: adrenocorticotropic hormone; DHEA: dehydroepiandrosterone; TIW: three times per week.