Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Endocrinology
Volume 2016 (2016), Article ID 5191903, 3 pages
http://dx.doi.org/10.1155/2016/5191903
Case Report

Occult Langerhans Cell Histiocytosis Presenting with Papillary Thyroid Carcinoma, a Thickened Pituitary Stalk and Diabetes Insipidus

1Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
2Division of Endocrinology, Allegheny Neuroendocrinology Center, Allegheny General Hospital, Drexel University College of Medicine, Pittsburgh, PA, USA

Received 8 June 2016; Revised 1 August 2016; Accepted 7 August 2016

Academic Editor: Takeshi Usui

Copyright © 2016 Michael S. Gordon and Murray B. Gordon. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Rupp and M. Molitch, “Pituitary stalk lesions,” Current Opinion in Endocrinology, Diabetes & Obesity, vol. 15, no. 4, pp. 339–345, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. E. M. Azouz, G. Saigal, M. M. Rodriguez, and A. Podda, “Langerhans' cell histiocytosis: pathology, imaging and treatment of skeletal involvement,” Pediatric Radiology, vol. 35, no. 2, pp. 103–115, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Makras, C. Samara, M. Antoniou et al., “Evolving radiological features of hypothalamo-pituitary lesions in adult patients with Langerhans cell histiocytosis (LCH),” Neuroradiology, vol. 48, no. 1, pp. 37–44, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Haupt, V. Nanduri, M. G. Calevo et al., “Permanent consequences in Langerhans cell histiocytosis patients: a pilot study from the Histiocyte Society—Late Effects Study Group,” Pediatric Blood and Cancer, vol. 42, no. 5, pp. 438–444, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Prosch, N. Grois, D. Prayer et al., “Central diabetes insipidus as presenting symptom of Langerhans cell histiocytosis,” Pediatric Blood and Cancer, vol. 43, no. 5, pp. 594–599, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. G. A. Kaltsas, T. B. Powles, J. Evanson et al., “Abnormalities in adult patients with Langerhans cell histiocytosis: clinical, endocrinological, and radiological features and response to treatment,” The Journal of Clinical Endocrinology & Metabolism, vol. 85, pp. 1370–1376, 2000. View at Google Scholar
  7. P. Makras, K. I. Alexandraki, G. P. Chrousos, A. B. Grossman, and G. A. Kaltsas, “Endocrine manifestations in Langerhans cell histiocytosis,” Trends in Endocrinology and Metabolism, vol. 18, no. 6, pp. 252–257, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Sangtian, T. Riangwiwat, S. Triamchaisri, W. Kanoksil, and C. Sriphrapradang, “Fine-needle aspiration biopsy of langerhans cell histiocytosis of thyroid gland,” Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 1, pp. 15–16, 2015. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Guarino, D. M. Giusti, A. Rubini et al., “Association between pituitary langerhans cell histiocytosis and papillary thyroid carcinoma,” Clinical Medicine Insights: Case Reports, vol. 6, pp. 197–200, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. D. K. Patten, Z. Wani, and N. Tolley, “Solitary Langerhans histiocytosis of the thyroid gland: a case report and literature review,” Head and Neck Pathology, vol. 6, no. 2, pp. 279–289, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Badalian-Very, J.-A. Vergilio, B. A. Degar et al., “Recurrent BRAF mutations in Langerhans cell histiocytosis,” Blood, vol. 116, no. 11, pp. 1919–1923, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Moschovi, M. Adamaki, S. Vlahopoulos, and C. Rodriguez-Galindo, “Synchronous and metachronous thyroid cancer in relation to Langerhans cell histiocytosis; involvement of V600E BRAF-mutation?” Pediatric Blood & Cancer, vol. 62, no. 1, pp. 173–174, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Dağlar-Aday, B. Toptaş, T. Öztürk et al., “Investigation of BRAF V600E mutation in papillary thyroid carcinoma and tumor-surrounding nontumoral tissues,” DNA and Cell Biology, vol. 32, no. 1, pp. 13–18, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Kumar, S. Angelini, E. Snellman, and K. Hemminki, “BRAF mutations are common somatic events in melanocytic nevi,” Journal of Investigative Dermatology, vol. 122, no. 2, pp. 342–348, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. M. S. Gordon and M. B. Gordon, “The thickened pituitary stalk with papillary carcinoma of the thyroid: a diagnostic conundrum,” in Proceedings of the 14th International Pituitary Congress, p. 61, San Diego, Calif, USA, March 2015.