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Case Reports in Endocrinology
Volume 2016, Article ID 6785925, 3 pages
http://dx.doi.org/10.1155/2016/6785925
Case Report

Plurihormonal Cosecretion by a Case of Adrenocortical Oncocytic Neoplasm

1Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario, Paseo de San Vicente No. 58, 37007 Salamanca, Spain
2Departamento de Medicina, Universidad de Salamanca, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain
3Centro de Investigación del Cáncer (IBMCC-CSIC/USAL) and Instituto Biosanitario de Salamanca, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain
4Unidad de Cirugía Endocrina, Departamento de Cirugía, Hospital Clínico Universitario de Salamanca, Paseo de San Vicente No. 58, 37007 Salamanca, Spain
5Servicio de Anatomía Patológica, Departamento de Anatomía Patológica, Hospital Universitario de Salamanca, Paseo de San Vicente No. 58, 37007 Salamanca, Spain

Received 15 February 2016; Accepted 18 May 2016

Academic Editor: Yuji Moriwaki

Copyright © 2016 J. J. Corrales et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Adrenocortical oncocytic neoplasms (oncocytomas) are extremely rare; only approximately 159 cases have been described so far. The majority are nonfunctional and benign. We describe an unusual case of a functional oncocytoma secreting an excess of glucocorticoids (cortisol) and androgens (androstenedione and DHEAS), a pattern of plurihormonal cosecretion previously not reported in men, presenting with endocrine manifestations of Cushing’s syndrome. The neoplasm was considered to be of uncertain malignant potential (borderline) according to the Lin-Weiss-Bisceglia criteria.