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Case Reports in Endocrinology
Volume 2018, Article ID 8046378, 3 pages
Case Report

Percutaneous Ethanol Injection in Combination with Laser Ablation for a 100 ml Partially Cystic Thyroid Nodule

Division of Endocrinology, “V. Fazzi” Hospital, Lecce, Italy

Correspondence should be addressed to Roberto Negro; ti.orebil@orgen.rd

Received 20 December 2017; Accepted 18 January 2018; Published 15 February 2018

Academic Editor: Osamu Isozaki

Copyright © 2018 Roberto Negro and Gabriele Greco. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Until nonsurgical techniques like laser ablation (LA) or radiofrequency became available, patients suffering from large nodules with compressive symptoms were addressed to surgery. We describe the case of a 59-year-old woman with a large, partially cystic thyroid nodule having a volume of about 100 ml. As the patient refused surgery, despite her constant local discomfort, such large partially cystic nodule underwent several percutaneous ethanol injections (PEI) and then was submitted to LA. The combination of these two procedures allowed firstly complete disappearance of the cystic component and secondly a significant reduction of thyroid nodule, which finally measured 17 ml in volume (82% reduction compared to baseline). This case demonstrates that even in very large partially cystic nodules LA preceded by PEI represents a valid alternative to surgery.