Hypertension Accompanied by Hyperaldosteronism, Hyperkalemia, and Hyperchloremic Acidosis: A Case Report and Literature Review

Table 2

Systematic review of clinical features and laboratory findings of GS patients with KLHL3 gene mutations.

ID	Mutation	Age (years)	Sex	BP	K^+	pH		PRA	PAC
Kelly et al. [2]	H498Y	18	M	150/90	7.3	7.34	18	0.2	19.1
Mitani et al. [3]	L387P	3	M	110/55	6.6	7.34	14.8	0.6	6.6
Park et al. [4]	C164F	0.8	F	115/72	6.3	7.34	19.6	<0.1	6.4
	S433N	1.7	F	110/73	6.9	7.30	12	<0.1	7.1
	S433N	23	F	Hypertension	6.4	NA	NA	NA	NA
Mayan et al. [5]	Q309R	69	F	115/78	5.4	NA	27	2.3	10.6
	Q309R	48	F	147/95	5.2	NA	25.7	0.1	4.1
	Q309R	11	M	104/61	6.4	NA	22.3	0.1	23.8
	Q309R	11	M	108/71	7.2	NA	21.5	0.1	14.0
	Q309R	10	F	103/72	5.3	NA	22.7	0.7	23.9
	R528H	38	F	154/77	5.6	NA	18	3.6	51.5
	R528H	15	F	136/77	6.0	NA	19.7	0.3	4.1
	R528H	13	F	124/77	6.2	NA	19.8	<0.3	14.8
	R528H	8	F	123/78	5.8	NA	19.1	0.7	10.7
	R528H	2	M	146/95	7.0	NA	NA	0.3	28.3
Kliuk et al. [6]	S553L	34	F	158/107	6.2	NA	NA	<0.5	15.5
	S553L	26	M	115/70	7.1	NA	NA	<0.5	6.5
	Q309R	63	M	110/80	5.6	NA	19.0	1.4	4.5
	Q309R	62	F	160/100	4.8	NA	23.6	1.7	8
	Q309R	57	M	120/90	5.1	NA	19.7	NA	16.7
	Q309R	54	M	145/105	6.4	NA	23.1	4.7	24.6
	Q309R	47	F	120/90	5.1	NA	23.8	2.5	21.8
	Q309R	47	F	145/110	5.1	NA	19.5	<1.0	NA
	Q309R	44	M	160/100	NA	NA	NA	NA	NA
	Q309R	18	M	110/70	5.2	NA	23.9	<0.5	NA
	Q309R	15	F	110/80	5.8	NA	20.2	<0.5	NA
	Q309R	12	F	114/76	5.3	NA	22	NA	NA
Present case	S433N	24	F	150/109	6.3	7.286	17.6	0.14	31.0