Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia

Table 1

Clinical, pathologic, and biochemical data of reported cases of malignant insulinoma in patients with diabetes mellitus.

Authors

Year

DM type

Age, sex

Site

Size (cm)

Metastases

Hypoglycemia symptoms

Insulin (μUI/ml)

C-peptide (ng/ml)

CgA (ng/ml)

Thyroid disease

Calcitonin (pg/ml)

Svartberg [12]

1996

1

33, F

Tail

Not reported

Liver; Ovaries

Unconsciousness

86

8.4

Not reported

No

Not reported

Siraji [18]

2006

2

74, F

Tail, head

7.3 × 5.7; 3 × 3; 3.1 × 1.8

Liver

Diaphoresis; Palpitations; Confusion; Seizures

39; (G: 28)

5.2

Not reported

No

Not reported

Schmitt [19]

2008

2

79, F

Body, tail

Not reported

Liver

Hunger; Dizziness; Tiredness

74; (G: 34)

9.7

↑ (404)

Hypothyroidism

Normal (<3)

FerrerGarcìa [20]

2011

2

78, M

Head

4.7 × 3

Liver

Not reported

23; (G: 35); (F)

4.6

↑ (834)

No

Not reported

Abbasakoor [21]

2011

2

67, F

Body

2.6 × 2; 5-6

Liver; Lymph nodes

Unconsciousness; Anxiety; Diaphoresis

91; (G: 19); (F)

8.2

Not reported

No

Not reported

Ademoglu [22]

2012

2

45, F

Head

0.8 × 0.7; 0.9 × 1; 0.7 × 0.7

Liver; Lymph nodes

Confusion; Diaphoresis

114; (G: 35); (F)

4.8

Not reported

No

Not reported

Lablanche [24]

2015

1

31, M

Head

6.3 × 5.6

Lymph nodes

Not reported

18; (G: 37); (F)

7.8

Not reported

Hashimoto thyroiditis

Not reported

Gjelberg [25]

2017

1

43, F

Tail

11 × 7

Liver; Lymph nodes

Not reported

9; (G: 45); (F)

1.6

↑ (323)

Hypothyroidism

Normal

Our patient

2019

2

66, M

Tail

4.3 × 2.2

Liver

Diaphoresis

89; (G:40)

4.2

↑ (1790)

Thyroid nodules

↑ (30)

G: glucose (mg/dl); F: fasting.