|
| | Index case | Sibling 1 | Sibling 2 | Sibling 3 | Sibling 4 | Father |
|
| Age at diagnosis (years) | 26 | 30 | 23 | 29 | 33 | 58 |
| Gender | Male | Male | Female | Female | Female | Male |
| Nodular goiter (±) | + | − | − | + | + | |
| Tumor diameter (cm) | 2.0 | 1.0 | 2.2 | 2.6 | 0.12 | |
| Histological variant of PTC | Classic | Classic | Classic | Classic | Follicular | |
| Laterality (unilateral/bilateral) | Unilateral | Unilateral | Unilateral | Bilateral | Unilateral | |
| Focality (unifocal/multifocal) | Multifocal | Unifocal | Unifocal | Multifocal | Unifocal | |
| Capsule invasion (±) | + | + | − | + | − | |
| Extrathyroid extension (±) | + | − | − | + | − | |
| Vascular/lymphatic invasion | + | − | − | + | − | |
| Hashimoto’s thyroiditis (±) | − | − | + | − | − | |
| Central LN involvement (±) | + | − | − | + | − | |
| Lateral LN involvement (±) | + | Not sampled | Not sampled | Not sampled | Not sampled | |
| Distant metastasis (±) | − | − | − | − | − | |
| pTNM classification | T4aN1bM0 | T1aN0M0 | T2N0M0 | T3bN1aM0 | T1aN0Mx | |
| Surgical procedures | Total thyroidectomy with bilateral neck dissection | Total thyroidectomy with central LN dissection | Total thyroidectomy with central LN dissection | Total thyroidectomy with central LN dissection | Total thyroidectomy with central LN dissection | |
| RAI ablation and dose | +, 100 mCi | +, 100 mCi | − | +, 30 mCi | − | |
| Persistence/recurrence of the disease (±) | + | − | − | + | − | |
| Repeated treatment (surgery and/or RAI and dose) | In February 2017, he received a 2nd dose of RAI (100 mCi) for local recurrence in the thyroid bed | − | − | In April 2019, surgery for thyroid recurrence with bilateral neck dissection and RAI (100 mCi) | − | |
| Death from the disease (±) | − | − | − | − | − | − |
| Duration of follow-up | Since April 2015 (75 months) | Since July 2015 (72 months) | Since November 2015 (68 months) | Since May 2016 (62 months) | Since August 2015 (71 months) | Since January 2018 (42 months) |
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