Adrenal and Hepatic Venous Sampling in a Case of Aldosterone-Producing Adrenocortical Carcinoma with Hepatic Metastasis

Figure 2

Results of histopathological and immunohistochemical investigation of left adrenal and liver biopsy specimens (magnification, ×200). Microscopic appearance (hematoxylin and eosin, HE, staining) showed eosinophilic tumor cell cytoplasm, nuclear atypia, diffuse architecture, and sinusoidal invasion. Immunohistochemical staining showed strong positive reactivity for SF-1, P450c17, 3βHSD2, P450c21, CYP11B1, and CYP11B2 and partial positive reactivity for P450scc and 3βHSD1 in both the left adrenal tumor (upper panel) and the liver tumor (lower panel). The DHEA-ST test result was negative for both specimens.