Case Report
Clavicular Metastasis as an Initial Presentation of Papillary Thyroid Cancer
Figure 5
Papillary thyroid carcinoma. (a) Fine-needle aspirate of the right side neck mass showing abundant clusters of neoplastic thyroid tissue, and nuclear grooves (arrow) are present (Diff Quick stain, 200x). (b) Cluster of neoplastic thyroid tissue from the neck mass with focal pseudoinclusions (arrow) in nuclei (PAP stain, 200x). (c) Histologic sections of the right side neck mass showing thyroid carcinoma with papillary nuclear features (nuclear overlap, nuclear grooves, and nuclear clearing), consistent with papillary thyroid carcinoma (H&E stain, 200x). (d) Histologic sections of the thyroid mass in the right lobe showing papillary thyroid carcinoma (H&E stain, 100x). (e) Immunohistochemistry for beta-catenin staining showing no evidence of nuclear staining corresponding to the section of the thyroid mass in D (immunohistochemical stain, 100x). (f) Papillary thyroid carcinoma (follicular variant) involving clavicle (H&E stain, 100x).
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