Recurrent Coagulopathy after Rattlesnake Bite Requiring Continuous Intravenous Dosing of Antivenom

Table 1

Serial coagulation panel.

Day	1		2			3		4				5			6
Time	1600	2259	0557	1415	2037	0411	1620	0004	0800	1535	2150	0353	1300	2359	0607	1210
Platelets × 10^3 mm^−3	20	493	528	416	352	293			200	263	335	341	219	141	115	116
PT, sec	150	29.8	16.9	15.5	15.6	15	14.6	15	15.5	15.1	15	14.6	14.3	15.7	15	14.5
INR	8	2.9	1.4	1.5	1.2	1.5	1.1	1.2	1.2	1.2	1.2	1.1	1.1	1.2	1.2	1.1
Fibrinogen, mg dL^−1	35	35	104	167	176	166	158	164	151	129	156	150	189	232	291	319
D-dimer, µg mL^−1	20	20	20				16.93	12.58	17.27	20	20	17.05	12.38	8.8	10.16	10.9
CroFab, time, and vials	1700 12		0715 2	1845 2					1342 4	1939 4	0152 2	0658 2			1048 1	1628 1
	2036 6		1220 2													2229 1
	2246 6
Day	7		8			9		10		11			12	19
Time	0005	1215	0000	1145	2005	0410	1246	0405	1810	0535	1315	1715	0640	0907
Platelets × 10^3 mm^−3	97	97	91	77	67	43	48	60	109	128	150		245	612
PT, sec	15.4	15	15.4	15.2	17.1	17.4	15.9	15.9	15.5	15.4	15.3	14.6	14.4	13
INR	1.2	1.2	1.2	1.2	1.4	1.4	1.3	1.3	1.2	1.2	1.2	1.1	1.1	1
Fibrinogen, mg dL^−1	394	452	495	305	110	111	183	195	314	243	261	267	282	464
D-dimer, µg mL^−1	8.17										4.53
CroFab, time, and vials					2241 1^†	0520 1^†	2331 1^†	1100 1^†	2235 1^†
						1048 1^†

CroFab infusion over 6 hours.