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Case Reports in Genetics
Volume 2012, Article ID 659016, 4 pages
http://dx.doi.org/10.1155/2012/659016
Case Report

Trisomy 11 as an Additional Chromosome Alteration in a Child with Acute Promyelocytic Leukemia with Poor Prognosis

1Faculty of Medical Sciences, State University of Rio de Janeiro, 20551-120 Rio de Janeiro, RJ, Brazil
2Bone Marrow Transplant Center, National Cancer Institute (INCA), 20551-120 Rio de Janeiro, RJ, Brazil
3Serviçio de Hematologia, Hospital Universitário Pedro Ernesto, Avenue 28 de Setembro no. 77, 3º andar, Vila Isabel, 20551-120 Rio de Janeiro, RJ, Brazil
4Hematology Service, HUCFF, UFRJ, 20551-120 Rio de Janeiro, RJ, Brazil
5Pronto Baby Children’s Hospital, 20551-120 Rio de Janeiro, RJ, Brazil

Received 14 February 2012; Accepted 11 June 2012

Academic Editors: P. D. Cotter, A. DeWan, B. Mittal, and A. M. Slavotinek

Copyright © 2012 Elenice Ferreira Bastos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The prognostic significance of the additional abnormalities to the t(15; 17) remains controversial. We report a case of promyelocytic leukemia (APL) in a ten-year-old boy. Classical and molecular cytogenetic (FISH) studies of a bone marrow sample obtained at diagnosis revealed the presence of trisomy of chromosome 11 as an additional chromosomal abnormality to the t(15; 17). The presence of the translocation t(15; 17), the cytogenetic marker of APL, is usually associated with good response to treatment with ATRA. In this case, although the patient had risk factors associated with good prognosis, he evolved and died quickly. So it seems that the presence of the trisomy 11 may be associated with disease progression and the poor outcome. To our knowledge, this is the first reported case of t(15; 17) associated with trisomy of chromosome 11 in a child with APL.